Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity

Blockade of CD28 costimulation with CTLA-4-Ig/Abatacept is used to dampen effector T cell responses in autoimmune and transplantation settings. However, a significant drawback of this approach is impaired regulatory T cell homeostasis that requires CD28 signaling. Therefore, strategies that restrict...

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Detalles Bibliográficos
Autores principales: Wang, Chun Jing, Petersone, Lina, Edner, Natalie M., Heuts, Frank, Ovcinnikovs, Vitalijs, Ntavli, Elisavet, Kogimtzis, Alexandros, Fabri, Astrid, Elfaki, Yassin, Houghton, Luke P., Hosse, Ralf J., Schubert, David A., Frei, Andreas P., Ross, Ellen M., Walker, Lucy S. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643453/
https://www.ncbi.nlm.nih.gov/pubmed/36347877
http://dx.doi.org/10.1038/s41467-022-34477-1

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