Single-nucleus transcriptomics of IDH1- and TP53-mutant glioma stem cells displays diversified commitment on invasive cancer progenitors

Glioma is a devastating brain tumor with a high mortality rate attributed to the glioma stem cells (GSCs) possessing high plasticity. Marker mutations in isocitrate dehydrogenase type 1 (IDH1) and tumor protein 53 (TP53) are frequent in gliomas and impact the cell fate decisions. Understanding the G...

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Detalles Bibliográficos
Autores principales: Gulaia, Valeriia, Shmelev, Mikhail, Romanishin, Aleksander, Shved, Nikita, Farniev, Vladislav, Goncharov, Nikolay, Biktimirov, Arthur, Vargas, Irene Lisa, Khodosevich, Konstantin, Kagansky, Alexander, Kumeiko, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643511/
https://www.ncbi.nlm.nih.gov/pubmed/36348001
http://dx.doi.org/10.1038/s41598-022-23646-3

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