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Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility

Acute primary angle closure glaucoma is a potentially blinding ophthalmic emergency requiring prompt treatment to lower the elevated intraocular pressure in humans and dogs. The PACG in most of canine breeds is epidemiologically similar to humans with older and female patients overrepresented with t...

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Autores principales: Park, Sangwan, Casanova, M. Isabel, Bannasch, Danika L., Daley, Nicole L., Kim, Soohyun, Kuchtey, John, Gomes, Filipe Espinheira, Leonard, Brian C., Good, Kathryn L., Martins, Bianca da C., Murphy, Christopher J., Thomasy, Sara M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643544/
https://www.ncbi.nlm.nih.gov/pubmed/36348026
http://dx.doi.org/10.1038/s41598-022-23238-1
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author Park, Sangwan
Casanova, M. Isabel
Bannasch, Danika L.
Daley, Nicole L.
Kim, Soohyun
Kuchtey, John
Gomes, Filipe Espinheira
Leonard, Brian C.
Good, Kathryn L.
Martins, Bianca da C.
Murphy, Christopher J.
Thomasy, Sara M.
author_facet Park, Sangwan
Casanova, M. Isabel
Bannasch, Danika L.
Daley, Nicole L.
Kim, Soohyun
Kuchtey, John
Gomes, Filipe Espinheira
Leonard, Brian C.
Good, Kathryn L.
Martins, Bianca da C.
Murphy, Christopher J.
Thomasy, Sara M.
author_sort Park, Sangwan
collection PubMed
description Acute primary angle closure glaucoma is a potentially blinding ophthalmic emergency requiring prompt treatment to lower the elevated intraocular pressure in humans and dogs. The PACG in most of canine breeds is epidemiologically similar to humans with older and female patients overrepresented with the condition. The American Cocker Spaniel (ACS) is among the most common breeds observed with PACG development in dogs. This study initially sought to identify genetic risk factors to explain the high prevalence of PACG in ACSs by using a case–control breed-matched genome-wide association study. However, the GWAS failed to identify candidate loci associated with PACG in this breed. This study then assessed intrinsic ocular morphologic traits that may relate to PACG susceptibility in this breed. Normal ACSs without glaucoma have a crowded anterior ocular segment and narrow iridocorneal angle and ciliary cleft, which is consistent with anatomical risk factors identified in humans. The ACSs showed unique features consisting of posterior bowing of iris and longer iridolenticular contact, which mirrors reverse pupillary block and pigment dispersion syndrome in humans. The ACS could hold potential to serve as an animal model of naturally occurring PACG in humans.
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spelling pubmed-96435442022-11-15 Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility Park, Sangwan Casanova, M. Isabel Bannasch, Danika L. Daley, Nicole L. Kim, Soohyun Kuchtey, John Gomes, Filipe Espinheira Leonard, Brian C. Good, Kathryn L. Martins, Bianca da C. Murphy, Christopher J. Thomasy, Sara M. Sci Rep Article Acute primary angle closure glaucoma is a potentially blinding ophthalmic emergency requiring prompt treatment to lower the elevated intraocular pressure in humans and dogs. The PACG in most of canine breeds is epidemiologically similar to humans with older and female patients overrepresented with the condition. The American Cocker Spaniel (ACS) is among the most common breeds observed with PACG development in dogs. This study initially sought to identify genetic risk factors to explain the high prevalence of PACG in ACSs by using a case–control breed-matched genome-wide association study. However, the GWAS failed to identify candidate loci associated with PACG in this breed. This study then assessed intrinsic ocular morphologic traits that may relate to PACG susceptibility in this breed. Normal ACSs without glaucoma have a crowded anterior ocular segment and narrow iridocorneal angle and ciliary cleft, which is consistent with anatomical risk factors identified in humans. The ACSs showed unique features consisting of posterior bowing of iris and longer iridolenticular contact, which mirrors reverse pupillary block and pigment dispersion syndrome in humans. The ACS could hold potential to serve as an animal model of naturally occurring PACG in humans. Nature Publishing Group UK 2022-11-08 /pmc/articles/PMC9643544/ /pubmed/36348026 http://dx.doi.org/10.1038/s41598-022-23238-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Park, Sangwan
Casanova, M. Isabel
Bannasch, Danika L.
Daley, Nicole L.
Kim, Soohyun
Kuchtey, John
Gomes, Filipe Espinheira
Leonard, Brian C.
Good, Kathryn L.
Martins, Bianca da C.
Murphy, Christopher J.
Thomasy, Sara M.
Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility
title Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility
title_full Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility
title_fullStr Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility
title_full_unstemmed Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility
title_short Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility
title_sort ocular morphologic traits in the american cocker spaniel may confer primary angle closure glaucoma susceptibility
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643544/
https://www.ncbi.nlm.nih.gov/pubmed/36348026
http://dx.doi.org/10.1038/s41598-022-23238-1
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