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Gender-related differentially expressed genes in pancreatic cancer: possible culprits or accomplices?

Pancreatic cancer (PC) is one of the leading causes of cancer mortality worldwide, and its incidence and mortality rate in several regions is higher in male patients. Although numerous efforts have been made to enhance the clinical outcomes of existing therapeutic regimens, their efficiency is still...

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Autores principales: Ramezankhani, Roya, Ghavidel, Afshin Abdi, Rashidi, Saadyeh, Rojhannezhad, Mahbubeh, Abolkheir, Hamid Reza, Mirhosseini, Malihe, Taleahmad, Sara, Vosough, Massoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643577/
https://www.ncbi.nlm.nih.gov/pubmed/36386839
http://dx.doi.org/10.3389/fgene.2022.966941
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author Ramezankhani, Roya
Ghavidel, Afshin Abdi
Rashidi, Saadyeh
Rojhannezhad, Mahbubeh
Abolkheir, Hamid Reza
Mirhosseini, Malihe
Taleahmad, Sara
Vosough, Massoud
author_facet Ramezankhani, Roya
Ghavidel, Afshin Abdi
Rashidi, Saadyeh
Rojhannezhad, Mahbubeh
Abolkheir, Hamid Reza
Mirhosseini, Malihe
Taleahmad, Sara
Vosough, Massoud
author_sort Ramezankhani, Roya
collection PubMed
description Pancreatic cancer (PC) is one of the leading causes of cancer mortality worldwide, and its incidence and mortality rate in several regions is higher in male patients. Although numerous efforts have been made to enhance the clinical outcomes of existing therapeutic regimens, their efficiency is still low, and drug resistance usually occurs in many patients. In addition, the exact underlying molecular basis that makes PC slightly more prevalent among males remains unknown. Providing information regarding the possible association between gender and PC tumorigenesis may offer important clues for how certain molecular cross-talks can affect PC initiation and/or progression. In this study, we used several microarray expression data to identify the common up- and downregulated genes within one specific gender, which were also specified to have binding sites for androgen and/or estrogen receptors. Using functional enrichment analysis among the others, for all the gene sets found in this study, we have shed light on the plausible importance of the androgenic effectors in tumorigenesis, such as the androgen-regulated expression of the GLI transcription factor and the potential role of testosterone in the extracellular matrix (ECM)–cell interaction, which are known for their importance in tumorigenesis. Moreover, we demonstrated that the biological process axon guidance was highlighted regarding the upregulated genes in male patients. Overall, identification of gene candidates as the possible link between gender and PC progression or survival rates may help in developing strategies to reduce the incidence of this cancer.
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spelling pubmed-96435772022-11-15 Gender-related differentially expressed genes in pancreatic cancer: possible culprits or accomplices? Ramezankhani, Roya Ghavidel, Afshin Abdi Rashidi, Saadyeh Rojhannezhad, Mahbubeh Abolkheir, Hamid Reza Mirhosseini, Malihe Taleahmad, Sara Vosough, Massoud Front Genet Genetics Pancreatic cancer (PC) is one of the leading causes of cancer mortality worldwide, and its incidence and mortality rate in several regions is higher in male patients. Although numerous efforts have been made to enhance the clinical outcomes of existing therapeutic regimens, their efficiency is still low, and drug resistance usually occurs in many patients. In addition, the exact underlying molecular basis that makes PC slightly more prevalent among males remains unknown. Providing information regarding the possible association between gender and PC tumorigenesis may offer important clues for how certain molecular cross-talks can affect PC initiation and/or progression. In this study, we used several microarray expression data to identify the common up- and downregulated genes within one specific gender, which were also specified to have binding sites for androgen and/or estrogen receptors. Using functional enrichment analysis among the others, for all the gene sets found in this study, we have shed light on the plausible importance of the androgenic effectors in tumorigenesis, such as the androgen-regulated expression of the GLI transcription factor and the potential role of testosterone in the extracellular matrix (ECM)–cell interaction, which are known for their importance in tumorigenesis. Moreover, we demonstrated that the biological process axon guidance was highlighted regarding the upregulated genes in male patients. Overall, identification of gene candidates as the possible link between gender and PC progression or survival rates may help in developing strategies to reduce the incidence of this cancer. Frontiers Media S.A. 2022-10-26 /pmc/articles/PMC9643577/ /pubmed/36386839 http://dx.doi.org/10.3389/fgene.2022.966941 Text en Copyright © 2022 Ramezankhani, Ghavidel, Rashidi, Rojhannezhad, Abolkheir, Mirhosseini, Taleahmad and Vosough. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Ramezankhani, Roya
Ghavidel, Afshin Abdi
Rashidi, Saadyeh
Rojhannezhad, Mahbubeh
Abolkheir, Hamid Reza
Mirhosseini, Malihe
Taleahmad, Sara
Vosough, Massoud
Gender-related differentially expressed genes in pancreatic cancer: possible culprits or accomplices?
title Gender-related differentially expressed genes in pancreatic cancer: possible culprits or accomplices?
title_full Gender-related differentially expressed genes in pancreatic cancer: possible culprits or accomplices?
title_fullStr Gender-related differentially expressed genes in pancreatic cancer: possible culprits or accomplices?
title_full_unstemmed Gender-related differentially expressed genes in pancreatic cancer: possible culprits or accomplices?
title_short Gender-related differentially expressed genes in pancreatic cancer: possible culprits or accomplices?
title_sort gender-related differentially expressed genes in pancreatic cancer: possible culprits or accomplices?
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643577/
https://www.ncbi.nlm.nih.gov/pubmed/36386839
http://dx.doi.org/10.3389/fgene.2022.966941
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