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Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams

The hypothalamic neuropeptide, oxytocin (Oxt), has been the focus of research for decades due to its effects on body physiology, neural circuits, and various behaviors. Oxt elicits a multitude of actions mainly through its receptor, the Oxt receptor (OxtR). Despite past research to understand the ce...

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Autores principales: Manjila, Steffy B., Betty, Rebecca, Kim, Yongsoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643707/
https://www.ncbi.nlm.nih.gov/pubmed/36389241
http://dx.doi.org/10.3389/fnins.2022.1044736
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author Manjila, Steffy B.
Betty, Rebecca
Kim, Yongsoo
author_facet Manjila, Steffy B.
Betty, Rebecca
Kim, Yongsoo
author_sort Manjila, Steffy B.
collection PubMed
description The hypothalamic neuropeptide, oxytocin (Oxt), has been the focus of research for decades due to its effects on body physiology, neural circuits, and various behaviors. Oxt elicits a multitude of actions mainly through its receptor, the Oxt receptor (OxtR). Despite past research to understand the central projections of Oxt neurons and OxtR- coupled signaling pathways in different brain areas, it remains unclear how this nonapeptide exhibits such pleiotropic effects while integrating external and internal information. Most reviews in the field either focus on neuroanatomy of the Oxt-OxtR system, or on the functional effects of Oxt in specific brain areas. Here, we provide a review by integrating brain wide connectivity of Oxt neurons and their downstream circuits with OxtR expression in mice. We categorize Oxt connected brain regions into three functional modules that regulate the internal state, somatic visceral, and cognitive response. Each module contains three neural circuits that process distinct behavioral effects. Broad innervations on functional circuits (e.g., basal ganglia for motor behavior) enable Oxt signaling to exert coordinated modulation in functionally inter-connected circuits. Moreover, Oxt acts as a neuromodulator of neuromodulations to broadly control the overall state of the brain. Lastly, we discuss the mismatch between Oxt projections and OxtR expression across various regions of the mouse brain. In summary, this review brings forth functional circuit-based analysis of Oxt connectivity across the whole brain in light of Oxt release and OxtR expression and provides a perspective guide to future studies.
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spelling pubmed-96437072022-11-15 Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams Manjila, Steffy B. Betty, Rebecca Kim, Yongsoo Front Neurosci Neuroscience The hypothalamic neuropeptide, oxytocin (Oxt), has been the focus of research for decades due to its effects on body physiology, neural circuits, and various behaviors. Oxt elicits a multitude of actions mainly through its receptor, the Oxt receptor (OxtR). Despite past research to understand the central projections of Oxt neurons and OxtR- coupled signaling pathways in different brain areas, it remains unclear how this nonapeptide exhibits such pleiotropic effects while integrating external and internal information. Most reviews in the field either focus on neuroanatomy of the Oxt-OxtR system, or on the functional effects of Oxt in specific brain areas. Here, we provide a review by integrating brain wide connectivity of Oxt neurons and their downstream circuits with OxtR expression in mice. We categorize Oxt connected brain regions into three functional modules that regulate the internal state, somatic visceral, and cognitive response. Each module contains three neural circuits that process distinct behavioral effects. Broad innervations on functional circuits (e.g., basal ganglia for motor behavior) enable Oxt signaling to exert coordinated modulation in functionally inter-connected circuits. Moreover, Oxt acts as a neuromodulator of neuromodulations to broadly control the overall state of the brain. Lastly, we discuss the mismatch between Oxt projections and OxtR expression across various regions of the mouse brain. In summary, this review brings forth functional circuit-based analysis of Oxt connectivity across the whole brain in light of Oxt release and OxtR expression and provides a perspective guide to future studies. Frontiers Media S.A. 2022-10-26 /pmc/articles/PMC9643707/ /pubmed/36389241 http://dx.doi.org/10.3389/fnins.2022.1044736 Text en Copyright © 2022 Manjila, Betty and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Manjila, Steffy B.
Betty, Rebecca
Kim, Yongsoo
Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams
title Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams
title_full Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams
title_fullStr Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams
title_full_unstemmed Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams
title_short Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams
title_sort missing pieces in decoding the brain oxytocin puzzle: functional insights from mouse brain wiring diagrams
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643707/
https://www.ncbi.nlm.nih.gov/pubmed/36389241
http://dx.doi.org/10.3389/fnins.2022.1044736
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