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Spontaneous remission of idiopathic minimal change disease in a cat

CASE SUMMARY: A 5-year-old female neutered domestic mediumhair cat presented with acute onset hyporexia, lethargy, ascites, hypoalbuminaemia and ventral subcutaneous oedema. Further investigations revealed a bicavitary effusion, myocardial injury, hypercholesterolaemia and concurrent marked proteinu...

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Autores principales: Broadbridge, Catherine, Hall, Harriet, McCallum, Katie E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643767/
https://www.ncbi.nlm.nih.gov/pubmed/36389213
http://dx.doi.org/10.1177/20551169221131261
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author Broadbridge, Catherine
Hall, Harriet
McCallum, Katie E
author_facet Broadbridge, Catherine
Hall, Harriet
McCallum, Katie E
author_sort Broadbridge, Catherine
collection PubMed
description CASE SUMMARY: A 5-year-old female neutered domestic mediumhair cat presented with acute onset hyporexia, lethargy, ascites, hypoalbuminaemia and ventral subcutaneous oedema. Further investigations revealed a bicavitary effusion, myocardial injury, hypercholesterolaemia and concurrent marked proteinuria. A panel of infectious disease tests yielded negative results. Nephrotic syndrome was suspected and renal biopsies were performed. Histopathology and electron microscopy confirmed a diagnosis of minimal change disease (MCD). The patient was successfully managed with benazepril, clopidogrel and a veterinary prescription renal diet. Follow-up two weeks later documented almost complete resolution of the cardiac abnormalities, absence of clinical signs and marked improvement in clinicopathological findings. The hypoalbuminaemia and proteinuria had resolved two months after presentation. At the time of writing, 13 months post-admission, the cat remained asymptomatic with no evidence of disease relapse. RELEVANCE AND NOVEL INFORMATION: MCD is rarely described in the veterinary literature, with only four cases reported to date. To our knowledge, this report describes the first case of successfully treated MCD-associated nephrotic syndrome in a cat without the use of glucocorticoid treatment.
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spelling pubmed-96437672022-11-15 Spontaneous remission of idiopathic minimal change disease in a cat Broadbridge, Catherine Hall, Harriet McCallum, Katie E JFMS Open Rep Case Report CASE SUMMARY: A 5-year-old female neutered domestic mediumhair cat presented with acute onset hyporexia, lethargy, ascites, hypoalbuminaemia and ventral subcutaneous oedema. Further investigations revealed a bicavitary effusion, myocardial injury, hypercholesterolaemia and concurrent marked proteinuria. A panel of infectious disease tests yielded negative results. Nephrotic syndrome was suspected and renal biopsies were performed. Histopathology and electron microscopy confirmed a diagnosis of minimal change disease (MCD). The patient was successfully managed with benazepril, clopidogrel and a veterinary prescription renal diet. Follow-up two weeks later documented almost complete resolution of the cardiac abnormalities, absence of clinical signs and marked improvement in clinicopathological findings. The hypoalbuminaemia and proteinuria had resolved two months after presentation. At the time of writing, 13 months post-admission, the cat remained asymptomatic with no evidence of disease relapse. RELEVANCE AND NOVEL INFORMATION: MCD is rarely described in the veterinary literature, with only four cases reported to date. To our knowledge, this report describes the first case of successfully treated MCD-associated nephrotic syndrome in a cat without the use of glucocorticoid treatment. SAGE Publications 2022-11-06 /pmc/articles/PMC9643767/ /pubmed/36389213 http://dx.doi.org/10.1177/20551169221131261 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Broadbridge, Catherine
Hall, Harriet
McCallum, Katie E
Spontaneous remission of idiopathic minimal change disease in a cat
title Spontaneous remission of idiopathic minimal change disease in a cat
title_full Spontaneous remission of idiopathic minimal change disease in a cat
title_fullStr Spontaneous remission of idiopathic minimal change disease in a cat
title_full_unstemmed Spontaneous remission of idiopathic minimal change disease in a cat
title_short Spontaneous remission of idiopathic minimal change disease in a cat
title_sort spontaneous remission of idiopathic minimal change disease in a cat
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643767/
https://www.ncbi.nlm.nih.gov/pubmed/36389213
http://dx.doi.org/10.1177/20551169221131261
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