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Case Report: (68)Ga-FAPI PET/CT, a more advantageous detection mean of gastric, peritoneal, and ovarian metastases from breast cancer
Breast cancer is the most common malignant tumor in adult women. Its common metastatic sites are lymph nodes, bones, lungs, the liver, and the brain. It is so rare for a patient with breast cancer to have metastases of the gastrointestinal tract, peritoneum, and ovary at the same time that the clini...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643837/ https://www.ncbi.nlm.nih.gov/pubmed/36387126 http://dx.doi.org/10.3389/fonc.2022.1013066 |
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author | Li, Tianyue Jiang, Xiaojing Zhang, Zhaoqi Chen, Xiaolin Wang, Jianfang Zhao, Xinming Zhang, Jingmian |
author_facet | Li, Tianyue Jiang, Xiaojing Zhang, Zhaoqi Chen, Xiaolin Wang, Jianfang Zhao, Xinming Zhang, Jingmian |
author_sort | Li, Tianyue |
collection | PubMed |
description | Breast cancer is the most common malignant tumor in adult women. Its common metastatic sites are lymph nodes, bones, lungs, the liver, and the brain. It is so rare for a patient with breast cancer to have metastases of the gastrointestinal tract, peritoneum, and ovary at the same time that the clinical reporting rate is low. We present a case of a 61-year-old woman who underwent right mastectomy and chemoradiotherapy 3 years ago because of mixed invasive ductal-lobular breast cancer. This time, she came to the hospital due to the symptom of stomach discomfort for 2 weeks. The gastroscopy biopsy result showed gastric metastasis from breast cancer. Then, (18)F-FDG imaging and (68)Ga-FAPI PET/CT imaging were performed for further diagnosis; (68)Ga-FAPI PET/CT demonstrated a significantly elevated FAPI activity in the thickened gastric wall, peritoneum, and bilateral adnexal areas, which was superior to that of (18)F-FDG. Finally, a biopsy of suspicious lesions was taken for pathological and histochemical examination, which confirmed that, in addition to the gastric metastasis, the peritoneum and bilateral ovaries were all consistent with metastatic breast cancer. |
format | Online Article Text |
id | pubmed-9643837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96438372022-11-15 Case Report: (68)Ga-FAPI PET/CT, a more advantageous detection mean of gastric, peritoneal, and ovarian metastases from breast cancer Li, Tianyue Jiang, Xiaojing Zhang, Zhaoqi Chen, Xiaolin Wang, Jianfang Zhao, Xinming Zhang, Jingmian Front Oncol Oncology Breast cancer is the most common malignant tumor in adult women. Its common metastatic sites are lymph nodes, bones, lungs, the liver, and the brain. It is so rare for a patient with breast cancer to have metastases of the gastrointestinal tract, peritoneum, and ovary at the same time that the clinical reporting rate is low. We present a case of a 61-year-old woman who underwent right mastectomy and chemoradiotherapy 3 years ago because of mixed invasive ductal-lobular breast cancer. This time, she came to the hospital due to the symptom of stomach discomfort for 2 weeks. The gastroscopy biopsy result showed gastric metastasis from breast cancer. Then, (18)F-FDG imaging and (68)Ga-FAPI PET/CT imaging were performed for further diagnosis; (68)Ga-FAPI PET/CT demonstrated a significantly elevated FAPI activity in the thickened gastric wall, peritoneum, and bilateral adnexal areas, which was superior to that of (18)F-FDG. Finally, a biopsy of suspicious lesions was taken for pathological and histochemical examination, which confirmed that, in addition to the gastric metastasis, the peritoneum and bilateral ovaries were all consistent with metastatic breast cancer. Frontiers Media S.A. 2022-10-26 /pmc/articles/PMC9643837/ /pubmed/36387126 http://dx.doi.org/10.3389/fonc.2022.1013066 Text en Copyright © 2022 Li, Jiang, Zhang, Chen, Wang, Zhao and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Li, Tianyue Jiang, Xiaojing Zhang, Zhaoqi Chen, Xiaolin Wang, Jianfang Zhao, Xinming Zhang, Jingmian Case Report: (68)Ga-FAPI PET/CT, a more advantageous detection mean of gastric, peritoneal, and ovarian metastases from breast cancer |
title | Case Report: (68)Ga-FAPI PET/CT, a more advantageous detection mean of gastric, peritoneal, and ovarian metastases from breast cancer |
title_full | Case Report: (68)Ga-FAPI PET/CT, a more advantageous detection mean of gastric, peritoneal, and ovarian metastases from breast cancer |
title_fullStr | Case Report: (68)Ga-FAPI PET/CT, a more advantageous detection mean of gastric, peritoneal, and ovarian metastases from breast cancer |
title_full_unstemmed | Case Report: (68)Ga-FAPI PET/CT, a more advantageous detection mean of gastric, peritoneal, and ovarian metastases from breast cancer |
title_short | Case Report: (68)Ga-FAPI PET/CT, a more advantageous detection mean of gastric, peritoneal, and ovarian metastases from breast cancer |
title_sort | case report: (68)ga-fapi pet/ct, a more advantageous detection mean of gastric, peritoneal, and ovarian metastases from breast cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643837/ https://www.ncbi.nlm.nih.gov/pubmed/36387126 http://dx.doi.org/10.3389/fonc.2022.1013066 |
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