Stable binding to phosphatidylserine-containing membranes requires conserved arginine residues in tandem C domains of blood coagulation factor VIII

At sites of vascular damage, factor VIII (fVIII) is proteolytically activated by thrombin and binds to activated platelet surfaces with activated factor IX (fIXa) to form the intrinsic “tenase” complex. Previous structural and mutational studies of fVIII have identified the C1 and C2 domains in bind...

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Detalles Bibliográficos
Autores principales: Peters, Shaun C., Childers, Kenneth C., Mitchell, Corbin E., Avery, Nathan G., Reese, Steven S., Mitchell, Cristopher, Wo, Serena W., Swanson, Christopher D., Brison, Caileen M., Spiegel, P. Clint
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643838/
https://www.ncbi.nlm.nih.gov/pubmed/36387287
http://dx.doi.org/10.3389/fmolb.2022.1040106

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