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Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima

Lung cancer is one of the malignant tumors with the fastest incidence rate and mortality growth and the greatest threat to human health and life. Marsdenia tenacissima is an antitumor of Chinese medicine. However, Marsdenia tenacissima has low bioavailability in the human body and most of its main a...

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Autores principales: Li, Runtian, Zhang, Zhiguang, Su, Xinxin, Yu, Jiaoneng, Lu, Lin, Liu, Tongxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643841/
https://www.ncbi.nlm.nih.gov/pubmed/36386222
http://dx.doi.org/10.3389/fphar.2022.1012063
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author Li, Runtian
Zhang, Zhiguang
Su, Xinxin
Yu, Jiaoneng
Lu, Lin
Liu, Tongxiang
author_facet Li, Runtian
Zhang, Zhiguang
Su, Xinxin
Yu, Jiaoneng
Lu, Lin
Liu, Tongxiang
author_sort Li, Runtian
collection PubMed
description Lung cancer is one of the malignant tumors with the fastest incidence rate and mortality growth and the greatest threat to human health and life. Marsdenia tenacissima is an antitumor of Chinese medicine. However, Marsdenia tenacissima has low bioavailability in the human body and most of its main active substances are aglycones, such as Tenacigenin A, Tenacigenin B. This study aims to produce biotransformation products rich in pungent saponins by using Marsdenia tenacissima as a fermentation medium of Ganoderma lucidum. Non-targeted metabolomics analysis was carried out on the fermentation products after the optimization process. A total of 249 differential metabolites were detected, and the content of saponins increased from 0.1% to 0.41% and most of them were tenacigenin. Furthermore, the biotransformation of C(21) steroidal glycosides in Marsdenia tenacissima was the central reaction in this fermentation process. Pharmacodynamics resewed that the anticancer effect of Marsdenia tenacissima was significantly enhanced after fermentation, mainly through inhibiting the growth and apoptosis of cancer cells.
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spelling pubmed-96438412022-11-15 Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima Li, Runtian Zhang, Zhiguang Su, Xinxin Yu, Jiaoneng Lu, Lin Liu, Tongxiang Front Pharmacol Pharmacology Lung cancer is one of the malignant tumors with the fastest incidence rate and mortality growth and the greatest threat to human health and life. Marsdenia tenacissima is an antitumor of Chinese medicine. However, Marsdenia tenacissima has low bioavailability in the human body and most of its main active substances are aglycones, such as Tenacigenin A, Tenacigenin B. This study aims to produce biotransformation products rich in pungent saponins by using Marsdenia tenacissima as a fermentation medium of Ganoderma lucidum. Non-targeted metabolomics analysis was carried out on the fermentation products after the optimization process. A total of 249 differential metabolites were detected, and the content of saponins increased from 0.1% to 0.41% and most of them were tenacigenin. Furthermore, the biotransformation of C(21) steroidal glycosides in Marsdenia tenacissima was the central reaction in this fermentation process. Pharmacodynamics resewed that the anticancer effect of Marsdenia tenacissima was significantly enhanced after fermentation, mainly through inhibiting the growth and apoptosis of cancer cells. Frontiers Media S.A. 2022-10-26 /pmc/articles/PMC9643841/ /pubmed/36386222 http://dx.doi.org/10.3389/fphar.2022.1012063 Text en Copyright © 2022 Li, Zhang, Su, Yu, Lu and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Runtian
Zhang, Zhiguang
Su, Xinxin
Yu, Jiaoneng
Lu, Lin
Liu, Tongxiang
Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima
title Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima
title_full Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima
title_fullStr Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima
title_full_unstemmed Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima
title_short Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima
title_sort nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for ganoderma lucidum with marsdenia tenacissima
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643841/
https://www.ncbi.nlm.nih.gov/pubmed/36386222
http://dx.doi.org/10.3389/fphar.2022.1012063
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