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Concurrent loss of MLH1, PMS2 and MSH6 immunoexpression in digestive system cancers indicating a widespread dysregulation in DNA repair processes

Immunohistochemical analysis of mismatch repair (MMR) protein expression is widely used to identify tumors with a deficient MMR (dMMR). MMR proteins (MLH1/PMS2 and MSH2/MSH6) work as functional heterodimers, which usually leads to the loss of expression in only one functional MMR heterodimer. Recent...

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Detalles Bibliográficos
Autores principales:	Reitsam, Nic Gabriel, Märkl, Bruno, Dintner, Sebastian, Waidhauser, Johanna, Vlasenko, Dmytro, Grosser, Bianca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643848/ https://www.ncbi.nlm.nih.gov/pubmed/36387226 http://dx.doi.org/10.3389/fonc.2022.1019798

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