Cargando…

Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents

RNA viral infections, including those caused by respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and Venezuelan Equine encephalitis virus (VEEV), pose a major global health challenge. Here, we report the synthesis and screening of a series of pyrrolo[2...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martinez-Gualda, Belén, Graus, Mirthe, Camps, Anita, Vanhulle, Emiel, Saul, Sirle, Azari, Siavash, Nhu Tran, Do Hoang, Vangeel, Laura, Chiu, Winston, Neyts, Johan, Schols, Dominique, Einav, Shirit, Vermeire, Kurt, De Jonghe, Steven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643853/ https://www.ncbi.nlm.nih.gov/pubmed/36385995 http://dx.doi.org/10.3389/fchem.2022.1058229

Ejemplares similares

Alkynyl Halo-Aza-Prins Annulative Couplings
por: Hernandez, Jackson J., et al.
Publicado: (2023)

Nickel-Catalyzed Amidation of Aryl Alkynyl Acids with Tetraalkylthiuram Disulfides: A Facile Synthesis of Aryl Alkynyl Amides
por: Wang, Longfei, et al.
Publicado: (2023)

Optimization of 4-Anilinoquinolines as Dengue Virus Inhibitors
por: Huang, Pei-Tzu, et al.
Publicado: (2021)

Intracellular flow cytometry complements RT-qPCR detection of circulating SARS-CoV-2 variants of concern
por: Vanhulle, Emiel, et al.
Publicado: (2022)

Double Arylation of the Indole Side Chain of Tri- and Tetrapodal Tryptophan Derivatives Renders Highly Potent HIV-1 and EV-A71 Entry Inhibitors†
por: Martí-Marí, Olaia, et al.
Publicado: (2021)

SARS-CoV-2 Permissive glioblastoma cell line for high throughput antiviral screening
por: Vanhulle, Emiel, et al.
Publicado: (2022)

The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection
por: Schor, Stanford, et al.
Publicado: (2022)

Palladium-Catalyzed Decarboxylative Coupling of Alkynyl Carboxylic Acids with Aryl Tosylates
por: Lee, Ju-Hyeon, et al.
Publicado: (2017)

Synthesis of N-, O-, and S-heterocycles from aryl/alkyl alkynyl aldehydes
por: Doraghi, Fatemeh, et al.
Publicado: (2023)

DMSO–allyl bromide: a mild and efficient reagent for atom economic one-pot N-allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles
por: Smile, Suresh Snoxma, et al.
Publicado: (2022)

Cellular electrical impedance to profile SARS-CoV-2 fusion inhibitors and to assess the fusogenic potential of spike mutants
por: Vanhulle, Emiel, et al.
Publicado: (2023)

Carbohydrate-binding protein from stinging nettle as fusion inhibitor for SARS-CoV-2 variants of concern
por: Vanhulle, Emiel, et al.
Publicado: (2022)

Problematic Ar(F)–Alkynyl Coupling with Fluorinated Aryls. From Partial Success with Alkynyl Stannanes to Efficient Solutions via Mechanistic Understanding of the Hidden Complexity
por: Marcos-Ayuso, Guillermo, et al.
Publicado: (2022)

Stereoselective synthesis of alkyl-, aryl-, vinyl- and alkynyl-substituted Z-enamides and enol ethers
por: Caramenti, Paola, et al.
Publicado: (2019)

Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies
por: Karim, Marwah, et al.
Publicado: (2022)

Gold(I)-Catalyzed Synthesis of 3-Sulfenyl Pyrroles and Indoles by a Regioselective Annulation of Alkynyl Thioethers
por: Simm, Peter E., et al.
Publicado: (2021)

Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration
por: Groves, Alistair, et al.
Publicado: (2020)

α-Perfluoroalkyl-β-alkynylation of alkenes via radical alkynyl migration
por: Tang, Xinjun, et al.
Publicado: (2017)

Ivermectin Does Not Protect against SARS-CoV-2 Infection in the Syrian Hamster Model
por: Foo, Caroline S., et al.
Publicado: (2022)

Au–Ag Bimetallic Catalysis: 3‐Alkynyl Benzofurans from Phenols via Tandem C−H Alkynylation/Oxy‐Alkynylation
por: Hu, Long, et al.
Publicado: (2021)

Recent Progress Concerning the N-Arylation of Indoles
por: Oeser, Petr, et al.
Publicado: (2021)

The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infection
por: Yao, Zhiyuan, et al.
Publicado: (2021)

Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues
por: Persoons, Leentje, et al.
Publicado: (2021)

Combating Intracellular Pathogens with Repurposed Host-Targeted Drugs
por: Schor, Stanford, et al.
Publicado: (2018)

Enantiospecific Alkynylation of Alkylboronic Esters
por: Wang, Yahui, et al.
Publicado: (2016)

Facile synthesis of 2-substituted benzo[b]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines
por: Rong, Zhouting, et al.
Publicado: (2019)

Reactant-induced photoactivation of in situ generated organogold intermediates leading to alkynylated indoles via Csp(2)-Csp cross-coupling
por: Zhao, Fen, et al.
Publicado: (2022)

Ruthenium‐Catalyzed C−H Arylation of Benzoic Acids and Indole Carboxylic Acids with Aryl Halides
por: Simonetti, Marco, et al.
Publicado: (2016)

Atroposelective synthesis of N-aryl peptoid atropisomers via a palladium(ii)-catalyzed asymmetric C–H alkynylation strategy
por: Wu, Yong-Jie, et al.
Publicado: (2021)

Turning Up Your Nose for a Flaviviral Encephalitis Cure
por: Barouch-Bentov, Rina, et al.
Publicado: (2018)

Cascade trifluoromethylthiolation and cyclization of N-[(3-aryl)propioloyl]indoles
por: Bi, Ming-Xi, et al.
Publicado: (2020)

Regioselective alkynylation followed by Suzuki coupling of 2,4-dichloroquinoline: Synthesis of 2-alkynyl-4-arylquinolines
por: Reddy, Ellanki Amarender, et al.
Publicado: (2009)

Microwave-Assisted aza-Friedel–Crafts Arylation of N-Acyliminium Ions: Expedient Access to 4-Aryl 3,4-Dihydroquinazolinones
por: Sawant, Rajiv T., et al.
Publicado: (2018)

Rhodium-catalysed ortho-alkynylation of nitroarenes
por: Tan, Eric, et al.
Publicado: (2021)

Cu(I)-Catalyzed Alkynylation of Quinolones
por: Maestro, Aitor, et al.
Publicado: (2022)

An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents
por: Dimopoulou, Athina, et al.
Publicado: (2015)

Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern
por: Vangeel, Laura, et al.
Publicado: (2022)

A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 Infection
por: Abdelnabi, Rana, et al.
Publicado: (2022)

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
por: Hubbard, Troy D., et al.
Publicado: (2015)

Catalytic α-Arylation of Imines Leading to N-Unprotected Indoles and Azaindoles
por: Marelli, Enrico, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5sv4o1qg8qf0b7l8msbn35bab8