Cargando…

A multifunctional drug consisting of tetracycline conjugated with odanacatib for efficient periodontitis therapy

The treatment of periodontitis can be very challenging due to its complex etiologies. A new pharmacologic strategy entitled “host-modulation therapy,” has been introduced to improve periodontal treatment outcomes. Supposedly, a multifunctional drug with the potential for bacterial infection preventi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Dengke, Zhang, Wuyang, Ye, Weiliang, Liu, Yuan, Li, Yuan, Wang, Yiming, Shi, Bingqing, Zheng, Xueni, An, Ying, Ma, Zhen, Hu, Kaijin, Zhou, Hongzhi, Xue, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643870/ https://www.ncbi.nlm.nih.gov/pubmed/36386169 http://dx.doi.org/10.3389/fphar.2022.1046451

Ejemplares similares

Cathepsin K deficiency promotes alveolar bone regeneration by promoting jaw bone marrow mesenchymal stem cells proliferation and differentiation via glycolysis pathway
por: Zhang, Wuyang, et al.
Publicado: (2021)

Potential role of odanacatib in the treatment of osteoporosis
por: Ng, Kong Wah
Publicado: (2012)

Traumatic temporomandibular joint bony ankylosis in growing rats
por: Ma, Zhen, et al.
Publicado: (2022)

Odanacatib for the treatment of postmenopausal osteoporosis: development history and design and participant characteristics of LOFT, the Long-Term Odanacatib Fracture Trial
por: Bone, H. G., et al.
Publicado: (2014)

Erratum to: Odanacatib for the treatment of postmenopausal osteoporosis: development history and design and participant characteristics of LOFT, the Long-Term Odanacatib Fracture Trial
por: Bone, H. G., et al.
Publicado: (2015)

Role of odanacatib in reducing bone loss due to endodontic disease: An overview
por: Bahuguna, Rachana, et al.
Publicado: (2016)

Odanacatib, a New Drug for the Treatment of Osteoporosis: Review of the Results in Postmenopausal Women
por: Pérez-Castrillón, José Luis, et al.
Publicado: (2010)

Effects of odanacatib on bone matrix mineralization in rhesus monkeys are similar to those of alendronate
por: Misof, Barbara M., et al.
Publicado: (2016)

Odanacatib, a Cathepsin K Cysteine Protease Inhibitor, Kills Hookworm In Vivo
por: Vermeire, Jon J., et al.
Publicado: (2016)

Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition
por: Wang, Yiming, et al.
Publicado: (2023)

The Bone Resorption Inhibitors Odanacatib and Alendronate Affect Post-Osteoclastic Events Differently in Ovariectomized Rabbits
por: Jensen, Pia Rosgaard, et al.
Publicado: (2013)

Odanacatib increases mineralized callus during fracture healing in a rabbit ulnar osteotomy model
por: Pennypacker, Brenda L., et al.
Publicado: (2015)

Pleiotropic Effects of Tetracyclines in the Management of COVID-19: Emerging Perspectives
por: Al-kuraishy, Hayder M., et al.
Publicado: (2021)

Pleiotropy of chemically modified tetracycline in periodontitis
por: Agarwal, Ashish
Publicado: (2013)

Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid
por: Xiong, Xifeng, et al.
Publicado: (2021)

Tetracycline-grafted mPEG-PLGA micelles for bone-targeting and osteoporotic improvement
por: Que, Yunduan, et al.
Publicado: (2022)

Multifunctional Nanosystems Powered Photodynamic Immunotherapy
por: Ma, Yunong, et al.
Publicado: (2022)

Ultrasmall PEI-Decorated Bi(2)Se(3) Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy
por: Zhang, Peng, et al.
Publicado: (2021)

Synthesis, Characterization, Cellular Uptake, and In Vitro Anticancer Activity of Fullerenol-Doxorubicin Conjugates
por: Xu, Beihua, et al.
Publicado: (2021)

Effect of tetracycline hydrochloride application on dental pulp stem cell metabolism–booster or obstacle for tissue engineering?
por: Wang, Wang, et al.
Publicado: (2023)

Consistency of recommendations for pharmacotherapy of rheumatoid arthritis
por: Hu, Yue, et al.
Publicado: (2022)

Multifunctional polymeric micelles for delivery of drugs and siRNA
por: Jhaveri, Aditi M., et al.
Publicado: (2014)

The effect of antibiotics on the periodontal treatment of diabetic patients with periodontitis: A systematic review and meta-analysis
por: Tang, Ziwei, et al.
Publicado: (2023)

Identification of ferroptosis, necroptosis, and pyroptosis-associated genes in periodontitis-affected human periodontal tissue using integrated bioinformatic analysis
por: Pan, Shuaifei, et al.
Publicado: (2023)

Targeted Therapeutic Strategies in the Battle Against Pathogenic Bacteria
por: Yang, Bingqing, et al.
Publicado: (2021)

Inhibition of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Regulates the Hepatobiliary Excretion and Plasma Exposure of Thienorphine and Its Glucuronide Conjugate
por: Kong, Ling-Lei, et al.
Publicado: (2016)

Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury
por: Zhang, Xinzhu, et al.
Publicado: (2022)

Periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased Dominican adults
por: Collins, James R., et al.
Publicado: (2015)

Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance
por: Rahman, Md. Mominur, et al.
Publicado: (2022)

Dual-Responsive Core Crosslinking Glycopolymer-Drug Conjugates Nanoparticles for Precise Hepatocarcinoma Therapy
por: Wu, Jing, et al.
Publicado: (2018)

Discovery of the Consistently Well-Performed Analysis Chain for SWATH-MS Based Pharmacoproteomic Quantification
por: Fu, Jianbo, et al.
Publicado: (2018)

Multifunctionality of biocrusts is positively predicted by network topologies consistent with interspecies facilitation
por: Li, Hua, et al.
Publicado: (2020)

NanoLuc Luciferase – A Multifunctional Tool for High Throughput Antibody Screening
por: Boute, Nicolas, et al.
Publicado: (2016)

Evaluation of commercially available biodegradable tetracycline fiber therapy in chronic periodontitis
por: Sachdeva, Surinder, et al.
Publicado: (2011)

Chemically modified tetracyclines: Novel therapeutic agents in the management of chronic periodontitis
por: Agnihotri, Rupali, et al.
Publicado: (2012)

Effect of tetracycline HCl in the treatment of chronic periodontitis – A clinical study
por: Sinha, Sachin, et al.
Publicado: (2014)

Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats
por: FERNANDES, Leandro Araújo, et al.
Publicado: (2010)

Long-term treatment with odanacatib maintains normal trabecular biomechanical properties in ovariectomized adult monkeys as demonstrated by micro-CT-based finite element analysis
por: Cabal, Antonio, et al.
Publicado: (2017)

Repositioning of Hypoglycemic Drug Linagliptin for Cancer Treatment
por: Li, Yong, et al.
Publicado: (2020)

Glycosaminoglycans as Multifunctional Anti-Elastase and Anti-Inflammatory Drugs in Cystic Fibrosis Lung Disease
por: Voynow, Judith A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_m37j7kpq7sa1pnlhatr1o5c3p0