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Study of thymus volume and density in COVID-19 patients: Is there a correlation in terms of pulmonary CT severity score?
BACKGROUND: Thymus has a pivotal role in combating infectious diseases. Although some reviews have been published about its critical role in COVID-19, there is not enough research. In this study, the size and density of thymus related to computed tomography pulmonary severity score (CT-SS) were rese...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643947/ http://dx.doi.org/10.1186/s43055-022-00917-7 |
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author | Alicioglu, Banu Bayav, Murat |
author_facet | Alicioglu, Banu Bayav, Murat |
author_sort | Alicioglu, Banu |
collection | PubMed |
description | BACKGROUND: Thymus has a pivotal role in combating infectious diseases. Although some reviews have been published about its critical role in COVID-19, there is not enough research. In this study, the size and density of thymus related to computed tomography pulmonary severity score (CT-SS) were researched. RESULTS: A total of 196 patients were analyzed with a mean age of 52.54 ± 18.78 years; 97 (49.5%) of them were RT-PCR (−) and 99 (50.5%) were RT-PCR (+). Within RT-PCR (+) group 62 (62.6%) of them had pneumonia with a mean CT-SS of 9.37 ± 8.83; within RT-PCR (−) group 20 (20.6%) of them had pneumonia with the mean CT-SS of 12.00 ± 10.18. CT-SS had moderate negative correlation with thymus volume and thymus maximum diameter in patients having nodular-type thymus (R = −0.591, P = 0.02; R = −0.515, P = 0.049, respectively). Homogenous fat infiltration was more commonly seen in RT-PCR (−) group while reticular and nodular types were commonly seen in RT-PCR (+) group (p = 0.015). The mean volume and maximum diameter of thymus were statistically significantly higher in RT-PCR (+) group (p = 0.027 and p = 0.048, respectively). CONCLUSION: This study showed the higher thymic volume and maximum diameter and more involution in COVID-19 patients. CT-SS had a moderate negative correlation with thymus volume and thymus maximum diameter. Pneumonia was more frequent in COVID patients, but mean CT-SS of the non-COVID cases was higher. |
format | Online Article Text |
id | pubmed-9643947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-96439472022-11-14 Study of thymus volume and density in COVID-19 patients: Is there a correlation in terms of pulmonary CT severity score? Alicioglu, Banu Bayav, Murat Egypt J Radiol Nucl Med Research BACKGROUND: Thymus has a pivotal role in combating infectious diseases. Although some reviews have been published about its critical role in COVID-19, there is not enough research. In this study, the size and density of thymus related to computed tomography pulmonary severity score (CT-SS) were researched. RESULTS: A total of 196 patients were analyzed with a mean age of 52.54 ± 18.78 years; 97 (49.5%) of them were RT-PCR (−) and 99 (50.5%) were RT-PCR (+). Within RT-PCR (+) group 62 (62.6%) of them had pneumonia with a mean CT-SS of 9.37 ± 8.83; within RT-PCR (−) group 20 (20.6%) of them had pneumonia with the mean CT-SS of 12.00 ± 10.18. CT-SS had moderate negative correlation with thymus volume and thymus maximum diameter in patients having nodular-type thymus (R = −0.591, P = 0.02; R = −0.515, P = 0.049, respectively). Homogenous fat infiltration was more commonly seen in RT-PCR (−) group while reticular and nodular types were commonly seen in RT-PCR (+) group (p = 0.015). The mean volume and maximum diameter of thymus were statistically significantly higher in RT-PCR (+) group (p = 0.027 and p = 0.048, respectively). CONCLUSION: This study showed the higher thymic volume and maximum diameter and more involution in COVID-19 patients. CT-SS had a moderate negative correlation with thymus volume and thymus maximum diameter. Pneumonia was more frequent in COVID patients, but mean CT-SS of the non-COVID cases was higher. Springer Berlin Heidelberg 2022-11-08 2022 /pmc/articles/PMC9643947/ http://dx.doi.org/10.1186/s43055-022-00917-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Alicioglu, Banu Bayav, Murat Study of thymus volume and density in COVID-19 patients: Is there a correlation in terms of pulmonary CT severity score? |
title | Study of thymus volume and density in COVID-19 patients: Is there a correlation in terms of pulmonary CT severity score? |
title_full | Study of thymus volume and density in COVID-19 patients: Is there a correlation in terms of pulmonary CT severity score? |
title_fullStr | Study of thymus volume and density in COVID-19 patients: Is there a correlation in terms of pulmonary CT severity score? |
title_full_unstemmed | Study of thymus volume and density in COVID-19 patients: Is there a correlation in terms of pulmonary CT severity score? |
title_short | Study of thymus volume and density in COVID-19 patients: Is there a correlation in terms of pulmonary CT severity score? |
title_sort | study of thymus volume and density in covid-19 patients: is there a correlation in terms of pulmonary ct severity score? |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643947/ http://dx.doi.org/10.1186/s43055-022-00917-7 |
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