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The effects of selenium supplementation on inflammatory markers in critically ill patients

ABSTRACT: Low serum selenium (Se) levels have been shown in critical illness, which is associated with poor clinical outcomes and a higher mortality rate. Se plays an important role in inflammation and oxidative stress. Since the overproduction of inflammatory cytokines and increased oxidative stres...

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Autores principales: Mahmoodpoor, Ata, Faramarzi, Elnaz, Reyhanifard, Anita, Shamekh, Ali, Nikanfar, Saba, Azizi-Zeinalhajlou, Akbar, Sanaie, Sarvin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643959/
https://www.ncbi.nlm.nih.gov/pubmed/36405547
http://dx.doi.org/10.1007/s42452-022-05208-4
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author Mahmoodpoor, Ata
Faramarzi, Elnaz
Reyhanifard, Anita
Shamekh, Ali
Nikanfar, Saba
Azizi-Zeinalhajlou, Akbar
Sanaie, Sarvin
author_facet Mahmoodpoor, Ata
Faramarzi, Elnaz
Reyhanifard, Anita
Shamekh, Ali
Nikanfar, Saba
Azizi-Zeinalhajlou, Akbar
Sanaie, Sarvin
author_sort Mahmoodpoor, Ata
collection PubMed
description ABSTRACT: Low serum selenium (Se) levels have been shown in critical illness, which is associated with poor clinical outcomes and a higher mortality rate. Se plays an important role in inflammation and oxidative stress. Since the overproduction of inflammatory cytokines and increased oxidative stress is a major component of critical illnesses, its supplementation has been demonstrated to have promising effects on critically ill patients. This study aims to review the evidence regarding the effects of Se supplementation on inflammatory and oxidative markers in critically ill patients. The literature review highlights alterations of inflammatory markers, including procalcitonin, leukocyte count, albumin, prealbumin, C-reactive protein (CRP), inflammatory cytokines, and cholesterol following Se supplementation in critically ill patients. Besides, the antioxidant properties of Se due to its presence in the structure of several selenoenzymes have been reported. ARTICLE HIGHLIGHTS: Low serum Se level have been shown in critical illness, which is associated with poor clinical outcome and higher mortality rate. Se plays an important role in inflammation and oxidative stress. Se supplementation can have promising effects by alterations of inflammatory markers and its antioxidant properties for critically ill patients.
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spelling pubmed-96439592022-11-14 The effects of selenium supplementation on inflammatory markers in critically ill patients Mahmoodpoor, Ata Faramarzi, Elnaz Reyhanifard, Anita Shamekh, Ali Nikanfar, Saba Azizi-Zeinalhajlou, Akbar Sanaie, Sarvin SN Appl Sci Review Paper ABSTRACT: Low serum selenium (Se) levels have been shown in critical illness, which is associated with poor clinical outcomes and a higher mortality rate. Se plays an important role in inflammation and oxidative stress. Since the overproduction of inflammatory cytokines and increased oxidative stress is a major component of critical illnesses, its supplementation has been demonstrated to have promising effects on critically ill patients. This study aims to review the evidence regarding the effects of Se supplementation on inflammatory and oxidative markers in critically ill patients. The literature review highlights alterations of inflammatory markers, including procalcitonin, leukocyte count, albumin, prealbumin, C-reactive protein (CRP), inflammatory cytokines, and cholesterol following Se supplementation in critically ill patients. Besides, the antioxidant properties of Se due to its presence in the structure of several selenoenzymes have been reported. ARTICLE HIGHLIGHTS: Low serum Se level have been shown in critical illness, which is associated with poor clinical outcome and higher mortality rate. Se plays an important role in inflammation and oxidative stress. Se supplementation can have promising effects by alterations of inflammatory markers and its antioxidant properties for critically ill patients. Springer International Publishing 2022-11-08 2022 /pmc/articles/PMC9643959/ /pubmed/36405547 http://dx.doi.org/10.1007/s42452-022-05208-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Paper
Mahmoodpoor, Ata
Faramarzi, Elnaz
Reyhanifard, Anita
Shamekh, Ali
Nikanfar, Saba
Azizi-Zeinalhajlou, Akbar
Sanaie, Sarvin
The effects of selenium supplementation on inflammatory markers in critically ill patients
title The effects of selenium supplementation on inflammatory markers in critically ill patients
title_full The effects of selenium supplementation on inflammatory markers in critically ill patients
title_fullStr The effects of selenium supplementation on inflammatory markers in critically ill patients
title_full_unstemmed The effects of selenium supplementation on inflammatory markers in critically ill patients
title_short The effects of selenium supplementation on inflammatory markers in critically ill patients
title_sort effects of selenium supplementation on inflammatory markers in critically ill patients
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643959/
https://www.ncbi.nlm.nih.gov/pubmed/36405547
http://dx.doi.org/10.1007/s42452-022-05208-4
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