Design, Synthesis, SAR, Pharmacokinetic Prediction of New 4-Quinolones as Anti-Microbial Agents

s of new 4-quinolone derivatives was synthesized by conventional heating method. For the synthesized compounds, we performed pharmacokinetic prediction, SAR and antimicrobial assay. The presence of halogen elements plays a key role in the biological activity that is clear by in vitro analysis. Targe...

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Autores principales: Dubal, G. G., Vachchharajani, P. R., Solanki, M. J., Shah, V. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643968/
https://www.ncbi.nlm.nih.gov/pubmed/36408421
http://dx.doi.org/10.1134/S1070363222100280
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author Dubal, G. G.
Vachchharajani, P. R.
Solanki, M. J.
Shah, V. H.
author_facet Dubal, G. G.
Vachchharajani, P. R.
Solanki, M. J.
Shah, V. H.
author_sort Dubal, G. G.
collection PubMed
description s of new 4-quinolone derivatives was synthesized by conventional heating method. For the synthesized compounds, we performed pharmacokinetic prediction, SAR and antimicrobial assay. The presence of halogen elements plays a key role in the biological activity that is clear by in vitro analysis. Target compounds exhibit moderate to significant activity near to standard marketed drugs like amoxycillin, chloramphenicol, ciprofloxacin, norfloxacin, griseofulvin, and nystatin.
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spelling pubmed-96439682022-11-14 Design, Synthesis, SAR, Pharmacokinetic Prediction of New 4-Quinolones as Anti-Microbial Agents Dubal, G. G. Vachchharajani, P. R. Solanki, M. J. Shah, V. H. Russ J Gen Chem Article s of new 4-quinolone derivatives was synthesized by conventional heating method. For the synthesized compounds, we performed pharmacokinetic prediction, SAR and antimicrobial assay. The presence of halogen elements plays a key role in the biological activity that is clear by in vitro analysis. Target compounds exhibit moderate to significant activity near to standard marketed drugs like amoxycillin, chloramphenicol, ciprofloxacin, norfloxacin, griseofulvin, and nystatin. Pleiades Publishing 2022-11-08 2022 /pmc/articles/PMC9643968/ /pubmed/36408421 http://dx.doi.org/10.1134/S1070363222100280 Text en © Pleiades Publishing, Ltd. 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Dubal, G. G.
Vachchharajani, P. R.
Solanki, M. J.
Shah, V. H.
Design, Synthesis, SAR, Pharmacokinetic Prediction of New 4-Quinolones as Anti-Microbial Agents
title Design, Synthesis, SAR, Pharmacokinetic Prediction of New 4-Quinolones as Anti-Microbial Agents
title_full Design, Synthesis, SAR, Pharmacokinetic Prediction of New 4-Quinolones as Anti-Microbial Agents
title_fullStr Design, Synthesis, SAR, Pharmacokinetic Prediction of New 4-Quinolones as Anti-Microbial Agents
title_full_unstemmed Design, Synthesis, SAR, Pharmacokinetic Prediction of New 4-Quinolones as Anti-Microbial Agents
title_short Design, Synthesis, SAR, Pharmacokinetic Prediction of New 4-Quinolones as Anti-Microbial Agents
title_sort design, synthesis, sar, pharmacokinetic prediction of new 4-quinolones as anti-microbial agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643968/
https://www.ncbi.nlm.nih.gov/pubmed/36408421
http://dx.doi.org/10.1134/S1070363222100280
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