The function of prohibitins in mitochondria and the clinical potentials

Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in eukaryotes...

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Autores principales: Oyang, Linda, Li, Jian, Jiang, Xianjie, Lin, Jinguan, Xia, Longzheng, Yang, Lixia, Tan, Shiming, Wu, Nayiyuan, Han, Yaqian, Yang, Yiqing, Luo, Xia, Li, Jinyun, Liao, Qianjin, Shi, Yingrui, Zhou, Yujuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643987/
https://www.ncbi.nlm.nih.gov/pubmed/36348375
http://dx.doi.org/10.1186/s12935-022-02765-x
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author Oyang, Linda
Li, Jian
Jiang, Xianjie
Lin, Jinguan
Xia, Longzheng
Yang, Lixia
Tan, Shiming
Wu, Nayiyuan
Han, Yaqian
Yang, Yiqing
Luo, Xia
Li, Jinyun
Liao, Qianjin
Shi, Yingrui
Zhou, Yujuan
author_facet Oyang, Linda
Li, Jian
Jiang, Xianjie
Lin, Jinguan
Xia, Longzheng
Yang, Lixia
Tan, Shiming
Wu, Nayiyuan
Han, Yaqian
Yang, Yiqing
Luo, Xia
Li, Jinyun
Liao, Qianjin
Shi, Yingrui
Zhou, Yujuan
author_sort Oyang, Linda
collection PubMed
description Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in eukaryotes, but they are mainly located in mitochondria. In the mitochondria, PHBs stabilize the structure of the mitochondrial membrane and regulate mitochondrial autophagy, mitochondrial dynamics, mitochondrial biogenesis and quality control, and mitochondrial unfolded protein response. PHBs has shown to be associated with many diseases, such as mitochondria diseases, cancers, infectious diseases, and so on. Some molecule targets of PHBs can interfere with the occurrence and development of diseases. Therefore, this review clarifies the functions of PHBs in mitochondria, and provides a summary of the potential values in clinics.
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spelling pubmed-96439872022-11-14 The function of prohibitins in mitochondria and the clinical potentials Oyang, Linda Li, Jian Jiang, Xianjie Lin, Jinguan Xia, Longzheng Yang, Lixia Tan, Shiming Wu, Nayiyuan Han, Yaqian Yang, Yiqing Luo, Xia Li, Jinyun Liao, Qianjin Shi, Yingrui Zhou, Yujuan Cancer Cell Int Review Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in eukaryotes, but they are mainly located in mitochondria. In the mitochondria, PHBs stabilize the structure of the mitochondrial membrane and regulate mitochondrial autophagy, mitochondrial dynamics, mitochondrial biogenesis and quality control, and mitochondrial unfolded protein response. PHBs has shown to be associated with many diseases, such as mitochondria diseases, cancers, infectious diseases, and so on. Some molecule targets of PHBs can interfere with the occurrence and development of diseases. Therefore, this review clarifies the functions of PHBs in mitochondria, and provides a summary of the potential values in clinics. BioMed Central 2022-11-08 /pmc/articles/PMC9643987/ /pubmed/36348375 http://dx.doi.org/10.1186/s12935-022-02765-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Oyang, Linda
Li, Jian
Jiang, Xianjie
Lin, Jinguan
Xia, Longzheng
Yang, Lixia
Tan, Shiming
Wu, Nayiyuan
Han, Yaqian
Yang, Yiqing
Luo, Xia
Li, Jinyun
Liao, Qianjin
Shi, Yingrui
Zhou, Yujuan
The function of prohibitins in mitochondria and the clinical potentials
title The function of prohibitins in mitochondria and the clinical potentials
title_full The function of prohibitins in mitochondria and the clinical potentials
title_fullStr The function of prohibitins in mitochondria and the clinical potentials
title_full_unstemmed The function of prohibitins in mitochondria and the clinical potentials
title_short The function of prohibitins in mitochondria and the clinical potentials
title_sort function of prohibitins in mitochondria and the clinical potentials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643987/
https://www.ncbi.nlm.nih.gov/pubmed/36348375
http://dx.doi.org/10.1186/s12935-022-02765-x
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