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Pancreatic β-cell hyper-O-GlcNAcylation leads to impaired glucose homeostasis in vivo

Protein O-GlcNAcylation is a nutrient and stress-sensitive protein post-translational modification (PTM). The addition of an O-GlcNAc molecule to proteins is catalyzed by O-GlcNAc transferase (OGT), whereas O-GlcNAcase (OGA) enzyme is responsible for removal of this PTM. Previous work showed that OG...

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Detalles Bibliográficos
Autores principales:	Jo, Seokwon, Pritchard, Samantha, Wong, Alicia, Avula, Nandini, Essawy, Ahmad, Hanover, John, Alejandro, Emilyn U.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644030/ https://www.ncbi.nlm.nih.gov/pubmed/36387851 http://dx.doi.org/10.3389/fendo.2022.1040014

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