Antisense oligonucleotides targeting ORF1b block replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

The ongoing COVID-19 pandemic continues to pose a need for new and efficient therapeutic strategies. We explored antisense therapy using oligonucleotides targeting the severe acute respiratory syndrome coronavirus (SARS-CoV-2) genome. We predicted in silico four antisense oligonucleotides (ASO gapme...

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Detalles Bibliográficos
Autores principales: Dhorne-Pollet, Sophie, Fitzpatrick, Christopher, Da Costa, Bruno, Bourgon, Clara, Eléouët, Jean-François, Meunier, Nicolas, Burzio, Verónica A., Delmas, Bernard, Barrey, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644129/
https://www.ncbi.nlm.nih.gov/pubmed/36386681
http://dx.doi.org/10.3389/fmicb.2022.915202

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