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Alcohol-induced brain deficit in alcohol dependence

Although numerous adverse effects of alcohol addiction on health, behavior, and brain function were widely reported, the neurobiological mechanism of alcohol dependence remains largely unknown. In this study, a total of twenty-nine patients with alcohol dependence and twenty-nine status-matched norm...

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Autores principales: Wang, Yanping, Sun, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644208/
https://www.ncbi.nlm.nih.gov/pubmed/36388224
http://dx.doi.org/10.3389/fneur.2022.1036164
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author Wang, Yanping
Sun, Bo
author_facet Wang, Yanping
Sun, Bo
author_sort Wang, Yanping
collection PubMed
description Although numerous adverse effects of alcohol addiction on health, behavior, and brain function were widely reported, the neurobiological mechanism of alcohol dependence remains largely unknown. In this study, a total of twenty-nine patients with alcohol dependence and twenty-nine status-matched normal controls (NCs) were recruited. Percent amplitude of fluctuation (PerAF) was applied to identify alcohol-related brain activity deficits. We found that alcohol dependence was associated with widespread differences in the left orbitofrontal cortex, right higher visual cortex, right supramarginal gyrus, right postcentral gyrus, and bilateral cerebellum posterior lobe with decreased PerAF, but no brain areas with increased PerAF differences were found. ROC curve showed that decreased PerAF revealed extremely high discriminatory power with a high AUC value of 0.953, as well as a high degree of sensitivity (96.6%) and specificity (86.2%), in distinguishing patients with alcohol dependence from NCs. In the alcohol dependence group, the amount of daily alcohol consumption showed significant negative correlations with the right cerebellum posterior lobe and right higher visual cortex. These findings suggest that the cerebellar-visual-orbitofrontal circuit was disturbed by alcohol dependence. The proposed new method of PerAF may be served as a potential biomarker to identify the regional brain activity deficits of alcohol dependence.
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spelling pubmed-96442082022-11-15 Alcohol-induced brain deficit in alcohol dependence Wang, Yanping Sun, Bo Front Neurol Neurology Although numerous adverse effects of alcohol addiction on health, behavior, and brain function were widely reported, the neurobiological mechanism of alcohol dependence remains largely unknown. In this study, a total of twenty-nine patients with alcohol dependence and twenty-nine status-matched normal controls (NCs) were recruited. Percent amplitude of fluctuation (PerAF) was applied to identify alcohol-related brain activity deficits. We found that alcohol dependence was associated with widespread differences in the left orbitofrontal cortex, right higher visual cortex, right supramarginal gyrus, right postcentral gyrus, and bilateral cerebellum posterior lobe with decreased PerAF, but no brain areas with increased PerAF differences were found. ROC curve showed that decreased PerAF revealed extremely high discriminatory power with a high AUC value of 0.953, as well as a high degree of sensitivity (96.6%) and specificity (86.2%), in distinguishing patients with alcohol dependence from NCs. In the alcohol dependence group, the amount of daily alcohol consumption showed significant negative correlations with the right cerebellum posterior lobe and right higher visual cortex. These findings suggest that the cerebellar-visual-orbitofrontal circuit was disturbed by alcohol dependence. The proposed new method of PerAF may be served as a potential biomarker to identify the regional brain activity deficits of alcohol dependence. Frontiers Media S.A. 2022-10-25 /pmc/articles/PMC9644208/ /pubmed/36388224 http://dx.doi.org/10.3389/fneur.2022.1036164 Text en Copyright © 2022 Wang and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Wang, Yanping
Sun, Bo
Alcohol-induced brain deficit in alcohol dependence
title Alcohol-induced brain deficit in alcohol dependence
title_full Alcohol-induced brain deficit in alcohol dependence
title_fullStr Alcohol-induced brain deficit in alcohol dependence
title_full_unstemmed Alcohol-induced brain deficit in alcohol dependence
title_short Alcohol-induced brain deficit in alcohol dependence
title_sort alcohol-induced brain deficit in alcohol dependence
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644208/
https://www.ncbi.nlm.nih.gov/pubmed/36388224
http://dx.doi.org/10.3389/fneur.2022.1036164
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