Lipid transfer proteins involved in plant–pathogen interactions and their molecular mechanisms

Nonspecific lipid transfer proteins (LTPs) are small, cysteine‐rich proteins that play numerous functional roles in plant growth and development, including cutin wax formation, pollen tube adhesion, cell expansion, seed development, germination, and adaptation to changing environmental conditions. LTPs contain eight conserved cysteine residues and a hydrophobic cavity that provides a wide variety of lipid‐binding specificities. As members of the pathogenesis‐related protein 14 family (PR14), many LTPs inhibit fungal or bacterial growth, and act as positive regulators in plant disease resistance. Over the past decade, these essential immunity‐related roles of LTPs in plant immune processes have been documented in a growing body of literature. In this review, we summarize the roles of LTPs in plant–pathogen interactions, emphasizing the underlying molecular mechanisms in plant immune responses and specific LTP functions.