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Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study

OBJECTIVES: To investigate sex-based differences in baseline values and longitudinal trajectories of health-related quality of life (HRQoL) in a large cohort of myocardial infarction (MI) survivors after adjusting for other important factors. DESIGN: Longitudinal cohort study. SETTING: Population-ba...

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Autores principales: Dondo, Tatendashe Bernadette, Munyombwe, Theresa, Hall, Marlous, Hurdus, Ben, Soloveva, Anzhela, Oliver, Gerard, Aktaa, Suleman, West, Robert M, Hall, Alistair S, Gale, Chris P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644325/
https://www.ncbi.nlm.nih.gov/pubmed/36351712
http://dx.doi.org/10.1136/bmjopen-2022-062508
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author Dondo, Tatendashe Bernadette
Munyombwe, Theresa
Hall, Marlous
Hurdus, Ben
Soloveva, Anzhela
Oliver, Gerard
Aktaa, Suleman
West, Robert M
Hall, Alistair S
Gale, Chris P
author_facet Dondo, Tatendashe Bernadette
Munyombwe, Theresa
Hall, Marlous
Hurdus, Ben
Soloveva, Anzhela
Oliver, Gerard
Aktaa, Suleman
West, Robert M
Hall, Alistair S
Gale, Chris P
author_sort Dondo, Tatendashe Bernadette
collection PubMed
description OBJECTIVES: To investigate sex-based differences in baseline values and longitudinal trajectories of health-related quality of life (HRQoL) in a large cohort of myocardial infarction (MI) survivors after adjusting for other important factors. DESIGN: Longitudinal cohort study. SETTING: Population-based longitudinal study the Evaluation of the Methods and Management of Acute Coronary Events study linked with national cardiovascular registry. Data were collected from 77 hospitals in England between 1 November 2011 and 24 June 2015. PARTICIPANTS: 9551 patients with MI. Patients were eligible for the study if they were ≥18 years of age. PRIMARY AND SECONDARY OUTCOME MEASURES: HRQoL was measured by EuroQol five-dimension, visual analogue scale (EQ-5D, EQ VAS) survey at baseline, 1, 6 and 12 months after discharge. Multi-level linear and logistic regression models coupled with inverse probability weighted propensity scoring were used to evaluate sex differences in HRQoL following MI. RESULTS: Of the 9551 patients with MI and complete data on sex, 25.1% (2,397) were women. At baseline, women reported lower HRQoL (EQ VAS (mean (SD) 59.8 (20.4) vs 64.5 (20.9)) (median (IQR) 60.00 (50.00–75.00) vs 70.00 (50.00–80.00))) (EQ-5D (mean (SD) 0.66 (0.31) vs 0.74 (0.28)) (median (IQR) 0.73 (0.52–0.85) vs 0.81 (0.62–1.00))) and were more likely to report problems in each HRQoL domain compared with men. In the covariate balanced and adjusted multi-level model sex differences in HRQoL persisted during follow-up, with lower EQ VAS and EQ-5D scores in women compared with men (adjusted EQ VAS model sex coefficient: −4.41, 95% CI −5.16 to −3.66 and adjusted EQ-5D model sex coefficient: −0.07, 95% CI −0.08 to −0.06). CONCLUSIONS: Women have lower HRQoL compared with men at baseline and during 12 months follow-up after MI. Tailored interventions for women following an MI could improve their quality of life. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov (NCT04598048, NCT01808027, NCT01819103
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spelling pubmed-96443252022-11-15 Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study Dondo, Tatendashe Bernadette Munyombwe, Theresa Hall, Marlous Hurdus, Ben Soloveva, Anzhela Oliver, Gerard Aktaa, Suleman West, Robert M Hall, Alistair S Gale, Chris P BMJ Open Cardiovascular Medicine OBJECTIVES: To investigate sex-based differences in baseline values and longitudinal trajectories of health-related quality of life (HRQoL) in a large cohort of myocardial infarction (MI) survivors after adjusting for other important factors. DESIGN: Longitudinal cohort study. SETTING: Population-based longitudinal study the Evaluation of the Methods and Management of Acute Coronary Events study linked with national cardiovascular registry. Data were collected from 77 hospitals in England between 1 November 2011 and 24 June 2015. PARTICIPANTS: 9551 patients with MI. Patients were eligible for the study if they were ≥18 years of age. PRIMARY AND SECONDARY OUTCOME MEASURES: HRQoL was measured by EuroQol five-dimension, visual analogue scale (EQ-5D, EQ VAS) survey at baseline, 1, 6 and 12 months after discharge. Multi-level linear and logistic regression models coupled with inverse probability weighted propensity scoring were used to evaluate sex differences in HRQoL following MI. RESULTS: Of the 9551 patients with MI and complete data on sex, 25.1% (2,397) were women. At baseline, women reported lower HRQoL (EQ VAS (mean (SD) 59.8 (20.4) vs 64.5 (20.9)) (median (IQR) 60.00 (50.00–75.00) vs 70.00 (50.00–80.00))) (EQ-5D (mean (SD) 0.66 (0.31) vs 0.74 (0.28)) (median (IQR) 0.73 (0.52–0.85) vs 0.81 (0.62–1.00))) and were more likely to report problems in each HRQoL domain compared with men. In the covariate balanced and adjusted multi-level model sex differences in HRQoL persisted during follow-up, with lower EQ VAS and EQ-5D scores in women compared with men (adjusted EQ VAS model sex coefficient: −4.41, 95% CI −5.16 to −3.66 and adjusted EQ-5D model sex coefficient: −0.07, 95% CI −0.08 to −0.06). CONCLUSIONS: Women have lower HRQoL compared with men at baseline and during 12 months follow-up after MI. Tailored interventions for women following an MI could improve their quality of life. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov (NCT04598048, NCT01808027, NCT01819103 BMJ Publishing Group 2022-11-08 /pmc/articles/PMC9644325/ /pubmed/36351712 http://dx.doi.org/10.1136/bmjopen-2022-062508 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Cardiovascular Medicine
Dondo, Tatendashe Bernadette
Munyombwe, Theresa
Hall, Marlous
Hurdus, Ben
Soloveva, Anzhela
Oliver, Gerard
Aktaa, Suleman
West, Robert M
Hall, Alistair S
Gale, Chris P
Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study
title Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study
title_full Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study
title_fullStr Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study
title_full_unstemmed Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study
title_short Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study
title_sort sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644325/
https://www.ncbi.nlm.nih.gov/pubmed/36351712
http://dx.doi.org/10.1136/bmjopen-2022-062508
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