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Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study
OBJECTIVES: To investigate sex-based differences in baseline values and longitudinal trajectories of health-related quality of life (HRQoL) in a large cohort of myocardial infarction (MI) survivors after adjusting for other important factors. DESIGN: Longitudinal cohort study. SETTING: Population-ba...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644325/ https://www.ncbi.nlm.nih.gov/pubmed/36351712 http://dx.doi.org/10.1136/bmjopen-2022-062508 |
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author | Dondo, Tatendashe Bernadette Munyombwe, Theresa Hall, Marlous Hurdus, Ben Soloveva, Anzhela Oliver, Gerard Aktaa, Suleman West, Robert M Hall, Alistair S Gale, Chris P |
author_facet | Dondo, Tatendashe Bernadette Munyombwe, Theresa Hall, Marlous Hurdus, Ben Soloveva, Anzhela Oliver, Gerard Aktaa, Suleman West, Robert M Hall, Alistair S Gale, Chris P |
author_sort | Dondo, Tatendashe Bernadette |
collection | PubMed |
description | OBJECTIVES: To investigate sex-based differences in baseline values and longitudinal trajectories of health-related quality of life (HRQoL) in a large cohort of myocardial infarction (MI) survivors after adjusting for other important factors. DESIGN: Longitudinal cohort study. SETTING: Population-based longitudinal study the Evaluation of the Methods and Management of Acute Coronary Events study linked with national cardiovascular registry. Data were collected from 77 hospitals in England between 1 November 2011 and 24 June 2015. PARTICIPANTS: 9551 patients with MI. Patients were eligible for the study if they were ≥18 years of age. PRIMARY AND SECONDARY OUTCOME MEASURES: HRQoL was measured by EuroQol five-dimension, visual analogue scale (EQ-5D, EQ VAS) survey at baseline, 1, 6 and 12 months after discharge. Multi-level linear and logistic regression models coupled with inverse probability weighted propensity scoring were used to evaluate sex differences in HRQoL following MI. RESULTS: Of the 9551 patients with MI and complete data on sex, 25.1% (2,397) were women. At baseline, women reported lower HRQoL (EQ VAS (mean (SD) 59.8 (20.4) vs 64.5 (20.9)) (median (IQR) 60.00 (50.00–75.00) vs 70.00 (50.00–80.00))) (EQ-5D (mean (SD) 0.66 (0.31) vs 0.74 (0.28)) (median (IQR) 0.73 (0.52–0.85) vs 0.81 (0.62–1.00))) and were more likely to report problems in each HRQoL domain compared with men. In the covariate balanced and adjusted multi-level model sex differences in HRQoL persisted during follow-up, with lower EQ VAS and EQ-5D scores in women compared with men (adjusted EQ VAS model sex coefficient: −4.41, 95% CI −5.16 to −3.66 and adjusted EQ-5D model sex coefficient: −0.07, 95% CI −0.08 to −0.06). CONCLUSIONS: Women have lower HRQoL compared with men at baseline and during 12 months follow-up after MI. Tailored interventions for women following an MI could improve their quality of life. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov (NCT04598048, NCT01808027, NCT01819103 |
format | Online Article Text |
id | pubmed-9644325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-96443252022-11-15 Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study Dondo, Tatendashe Bernadette Munyombwe, Theresa Hall, Marlous Hurdus, Ben Soloveva, Anzhela Oliver, Gerard Aktaa, Suleman West, Robert M Hall, Alistair S Gale, Chris P BMJ Open Cardiovascular Medicine OBJECTIVES: To investigate sex-based differences in baseline values and longitudinal trajectories of health-related quality of life (HRQoL) in a large cohort of myocardial infarction (MI) survivors after adjusting for other important factors. DESIGN: Longitudinal cohort study. SETTING: Population-based longitudinal study the Evaluation of the Methods and Management of Acute Coronary Events study linked with national cardiovascular registry. Data were collected from 77 hospitals in England between 1 November 2011 and 24 June 2015. PARTICIPANTS: 9551 patients with MI. Patients were eligible for the study if they were ≥18 years of age. PRIMARY AND SECONDARY OUTCOME MEASURES: HRQoL was measured by EuroQol five-dimension, visual analogue scale (EQ-5D, EQ VAS) survey at baseline, 1, 6 and 12 months after discharge. Multi-level linear and logistic regression models coupled with inverse probability weighted propensity scoring were used to evaluate sex differences in HRQoL following MI. RESULTS: Of the 9551 patients with MI and complete data on sex, 25.1% (2,397) were women. At baseline, women reported lower HRQoL (EQ VAS (mean (SD) 59.8 (20.4) vs 64.5 (20.9)) (median (IQR) 60.00 (50.00–75.00) vs 70.00 (50.00–80.00))) (EQ-5D (mean (SD) 0.66 (0.31) vs 0.74 (0.28)) (median (IQR) 0.73 (0.52–0.85) vs 0.81 (0.62–1.00))) and were more likely to report problems in each HRQoL domain compared with men. In the covariate balanced and adjusted multi-level model sex differences in HRQoL persisted during follow-up, with lower EQ VAS and EQ-5D scores in women compared with men (adjusted EQ VAS model sex coefficient: −4.41, 95% CI −5.16 to −3.66 and adjusted EQ-5D model sex coefficient: −0.07, 95% CI −0.08 to −0.06). CONCLUSIONS: Women have lower HRQoL compared with men at baseline and during 12 months follow-up after MI. Tailored interventions for women following an MI could improve their quality of life. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov (NCT04598048, NCT01808027, NCT01819103 BMJ Publishing Group 2022-11-08 /pmc/articles/PMC9644325/ /pubmed/36351712 http://dx.doi.org/10.1136/bmjopen-2022-062508 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Cardiovascular Medicine Dondo, Tatendashe Bernadette Munyombwe, Theresa Hall, Marlous Hurdus, Ben Soloveva, Anzhela Oliver, Gerard Aktaa, Suleman West, Robert M Hall, Alistair S Gale, Chris P Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study |
title | Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study |
title_full | Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study |
title_fullStr | Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study |
title_full_unstemmed | Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study |
title_short | Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study |
title_sort | sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644325/ https://www.ncbi.nlm.nih.gov/pubmed/36351712 http://dx.doi.org/10.1136/bmjopen-2022-062508 |
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