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Stability Convergence in Antibody Coformulations
[Image: see text] Combined administration of antibody therapeutics has proven to be beneficial for patients with cancer or infectious diseases. As a result, there is a growing trend toward multiple antibodies premixed into a single product form and delivered to patients as a fixed-dose coformulation...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644375/ https://www.ncbi.nlm.nih.gov/pubmed/36264768 http://dx.doi.org/10.1021/acs.molpharmaceut.2c00534 |
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author | Zhang, Hongyu Dalby, Paul A. |
author_facet | Zhang, Hongyu Dalby, Paul A. |
author_sort | Zhang, Hongyu |
collection | PubMed |
description | [Image: see text] Combined administration of antibody therapeutics has proven to be beneficial for patients with cancer or infectious diseases. As a result, there is a growing trend toward multiple antibodies premixed into a single product form and delivered to patients as a fixed-dose coformulation. However, combining antibodies into a single coformulation could be challenging as proteins have the potential to interact and alter their stability and degradation profiles in the mixture, compared to that in isolation. We show that in two specific antibody–antibody coformulations, the more stable antibody component increased the stability of the less stable component, which in return destabilized the more stable component, hence exhibiting an overall convergence of stability in the coformulation. |
format | Online Article Text |
id | pubmed-9644375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-96443752022-11-15 Stability Convergence in Antibody Coformulations Zhang, Hongyu Dalby, Paul A. Mol Pharm [Image: see text] Combined administration of antibody therapeutics has proven to be beneficial for patients with cancer or infectious diseases. As a result, there is a growing trend toward multiple antibodies premixed into a single product form and delivered to patients as a fixed-dose coformulation. However, combining antibodies into a single coformulation could be challenging as proteins have the potential to interact and alter their stability and degradation profiles in the mixture, compared to that in isolation. We show that in two specific antibody–antibody coformulations, the more stable antibody component increased the stability of the less stable component, which in return destabilized the more stable component, hence exhibiting an overall convergence of stability in the coformulation. American Chemical Society 2022-10-20 2022-11-07 /pmc/articles/PMC9644375/ /pubmed/36264768 http://dx.doi.org/10.1021/acs.molpharmaceut.2c00534 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Zhang, Hongyu Dalby, Paul A. Stability Convergence in Antibody Coformulations |
title | Stability
Convergence in Antibody Coformulations |
title_full | Stability
Convergence in Antibody Coformulations |
title_fullStr | Stability
Convergence in Antibody Coformulations |
title_full_unstemmed | Stability
Convergence in Antibody Coformulations |
title_short | Stability
Convergence in Antibody Coformulations |
title_sort | stability
convergence in antibody coformulations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644375/ https://www.ncbi.nlm.nih.gov/pubmed/36264768 http://dx.doi.org/10.1021/acs.molpharmaceut.2c00534 |
work_keys_str_mv | AT zhanghongyu stabilityconvergenceinantibodycoformulations AT dalbypaula stabilityconvergenceinantibodycoformulations |