Cargando…
Tissue management in precision medicine: What the pathologist needs to know in the molecular era
Precision medicine is “an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person.” Among many medical specialists involved in precision medicine, the pathologists play an important and key role in the...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644376/ https://www.ncbi.nlm.nih.gov/pubmed/36387281 http://dx.doi.org/10.3389/fmolb.2022.983102 |
_version_ | 1784826728682618880 |
---|---|
author | Souza da Silva, Ricella Pinto, Regina Cirnes, Luis Schmitt, Fernando |
author_facet | Souza da Silva, Ricella Pinto, Regina Cirnes, Luis Schmitt, Fernando |
author_sort | Souza da Silva, Ricella |
collection | PubMed |
description | Precision medicine is “an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person.” Among many medical specialists involved in precision medicine, the pathologists play an important and key role in the implementation and development of molecular tests that are in the center of decision of many therapeutic choices. Besides many laboratory procedures directly involved in the molecular tests, is fundamental to guarantee that tissues and cells collected for analysis be managed correctly before the DNA/RNA extraction. In this paper we explore the pivotal and interconnected points that can influence molecular studies, such as pre-analytical issues (fixation and decalcification); diagnosis and material selection, including the calculation of nuclei neoplastic fraction. The standardization of sample processing and morphological control ensures the accuracy of the diagnosis. Tissue or cytological samples constitutes the main foundation for the determination of biomarkers and development of druggable targets. Pathology and precision oncology still have a long way to go in terms of research and clinical practice: improving the accuracy and dissemination of molecular tests, learning in molecular tumor boards for advanced disease, and knowledge about early disease. Precision medicine needs pathology to be precise. |
format | Online Article Text |
id | pubmed-9644376 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96443762022-11-15 Tissue management in precision medicine: What the pathologist needs to know in the molecular era Souza da Silva, Ricella Pinto, Regina Cirnes, Luis Schmitt, Fernando Front Mol Biosci Molecular Biosciences Precision medicine is “an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person.” Among many medical specialists involved in precision medicine, the pathologists play an important and key role in the implementation and development of molecular tests that are in the center of decision of many therapeutic choices. Besides many laboratory procedures directly involved in the molecular tests, is fundamental to guarantee that tissues and cells collected for analysis be managed correctly before the DNA/RNA extraction. In this paper we explore the pivotal and interconnected points that can influence molecular studies, such as pre-analytical issues (fixation and decalcification); diagnosis and material selection, including the calculation of nuclei neoplastic fraction. The standardization of sample processing and morphological control ensures the accuracy of the diagnosis. Tissue or cytological samples constitutes the main foundation for the determination of biomarkers and development of druggable targets. Pathology and precision oncology still have a long way to go in terms of research and clinical practice: improving the accuracy and dissemination of molecular tests, learning in molecular tumor boards for advanced disease, and knowledge about early disease. Precision medicine needs pathology to be precise. Frontiers Media S.A. 2022-10-26 /pmc/articles/PMC9644376/ /pubmed/36387281 http://dx.doi.org/10.3389/fmolb.2022.983102 Text en Copyright © 2022 Souza da Silva, Pinto, Cirnes and Schmitt. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Souza da Silva, Ricella Pinto, Regina Cirnes, Luis Schmitt, Fernando Tissue management in precision medicine: What the pathologist needs to know in the molecular era |
title | Tissue management in precision medicine: What the pathologist needs to know in the molecular era |
title_full | Tissue management in precision medicine: What the pathologist needs to know in the molecular era |
title_fullStr | Tissue management in precision medicine: What the pathologist needs to know in the molecular era |
title_full_unstemmed | Tissue management in precision medicine: What the pathologist needs to know in the molecular era |
title_short | Tissue management in precision medicine: What the pathologist needs to know in the molecular era |
title_sort | tissue management in precision medicine: what the pathologist needs to know in the molecular era |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644376/ https://www.ncbi.nlm.nih.gov/pubmed/36387281 http://dx.doi.org/10.3389/fmolb.2022.983102 |
work_keys_str_mv | AT souzadasilvaricella tissuemanagementinprecisionmedicinewhatthepathologistneedstoknowinthemolecularera AT pintoregina tissuemanagementinprecisionmedicinewhatthepathologistneedstoknowinthemolecularera AT cirnesluis tissuemanagementinprecisionmedicinewhatthepathologistneedstoknowinthemolecularera AT schmittfernando tissuemanagementinprecisionmedicinewhatthepathologistneedstoknowinthemolecularera |