Cargando…

Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin

[Image: see text] Proteins, and in particular whey proteins, have recently been introduced as a promising excipient class for stabilizing amorphous solid dispersions. However, despite the efficacy of the approach, the molecular mechanisms behind the stabilization of the drug in the amorphous form ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kabedev, Aleksei, Zhuo, Xuezhi, Leng, Donglei, Foderà, Vito, Zhao, Min, Larsson, Per, Bergström, Christel A. S., Löbmann, Korbinian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644381/ https://www.ncbi.nlm.nih.gov/pubmed/36135343 http://dx.doi.org/10.1021/acs.molpharmaceut.2c00397

Ejemplares similares

Multivariate Quantification of the Solid State Phase Composition of Co-Amorphous Naproxen-Indomethacin
por: Beyer, Andreas, et al.
Publicado: (2015)

The Influence of Pressure on the Intrinsic Dissolution Rate of Amorphous Indomethacin
por: Löbmann, Korbinian, et al.
Publicado: (2014)

Microwave-Induced In Situ Amorphization: A New Strategy for Tackling the Stability Issue of Amorphous Solid Dispersions
por: Qiang, Wei, et al.
Publicado: (2020)

A Comparative Study between A Protein Based Amorphous Formulation and Other Dissolution Rate Enhancing Approaches: A Case Study with Rifaximin
por: Zhuo, Xuezhi, et al.
Publicado: (2022)

Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning
por: Hossain, Shakhawath, et al.
Publicado: (2019)

Thermal Stability of Amorphous Solid Dispersions
por: Jelić, Dijana
Publicado: (2021)

Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms
por: Ansari, Shaquib Rahman, et al.
Publicado: (2022)

Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways
por: Edueng, Khadijah, et al.
Publicado: (2017)

Characterization of Amorphous and Co-Amorphous Simvastatin Formulations Prepared by Spray Drying
por: Craye, Goedele, et al.
Publicado: (2015)

Stabilizing Effect of Soluplus on Erlotinib Metastable Crystal Form in Microparticles and Amorphous Solid Dispersions
por: Jia, Shuyu, et al.
Publicado: (2022)

The interplay of dissolution, solution crystallization and solid-state transformation of amorphous indomethacin in aqueous solution
por: Schneider, Raj, et al.
Publicado: (2020)

Preparation, Characterization and Stability Studies of Glassy Solid Dispersions of Indomethacin using PVP and Isomalt as carriers
por: Khodaverdi, Elham, et al.
Publicado: (2012)

Influence of Solvent Composition on the Performance of Spray-Dried Co-Amorphous Formulations
por: Mishra, Jaya, et al.
Publicado: (2018)

Hot Melt Coating of Amorphous Carvedilol
por: Bannow, Jacob, et al.
Publicado: (2020)

Direct Measurement of Amorphous Solubility
por: Štukelj, Jernej, et al.
Publicado: (2019)

Co-Amorphous Drug Formulations in Numbers: Recent Advances in Co-Amorphous Drug Formulations with Focus on Co-Formability, Molar Ratio, Preparation Methods, Physical Stability, In Vitro and In Vivo Performance, and New Formulation Strategies
por: Liu, Jingwen, et al.
Publicado: (2021)

Cellulose based polymers in development of amorphous solid dispersions
por: Chavan, Rahul B, et al.
Publicado: (2019)

Preparation and Characterization of Amorphous Solid Dispersions for the Solubilization of Fenretinide
por: Zuccari, Guendalina, et al.
Publicado: (2023)

Amorphous Solid Dispersion as Drug Delivery Vehicles in Cancer
por: Budiman, Arif, et al.
Publicado: (2023)

Convection-Induced vs. Microwave Radiation-Induced in situ Drug Amorphization
por: Hempel, Nele-Johanna, et al.
Publicado: (2020)

Amorphous Solid Dispersion of Epigallocatechin Gallate for Enhanced Physical Stability and Controlled Release
por: Cao, Yizheng, et al.
Publicado: (2017)

Oral Delivery of Niclosamide as an Amorphous Solid Dispersion That Generates Amorphous Nanoparticles during Dissolution
por: Jara, Miguel O., et al.
Publicado: (2022)

Molecular insights into alginate β‐lactoglobulin A multivalencies—The foundation for their amorphous aggregates and coacervation
por: Madsen, Mikkel, et al.
Publicado: (2023)

Intrinsic lipolysis rate for systematic design of lipid-based formulations
por: Jacobsen, Ann-Christin, et al.
Publicado: (2022)

Influence of Drug Load on the Printability and Solid-State Properties of 3D-Printed Naproxen-Based Amorphous Solid Dispersion
por: Kissi, Eric Ofosu, et al.
Publicado: (2021)

Amorphization of Thiamine Mononitrate: A Study of Crystallization Inhibition and Chemical Stability of Thiamine in Thiamine Mononitrate Amorphous Solid Dispersions
por: Arioglu-Tuncil, Seda, et al.
Publicado: (2020)

Improving Co-Amorphous Drug Formulations by the Addition of the Highly Water Soluble Amino Acid, Proline
por: Jensen, Katrine Tarp, et al.
Publicado: (2014)

Solid Dispersion Matrix Tablet Comprising Indomethacin-PEG-HPMC Fabricated with Fusion and Mold Technique
por: Mesnukul, A., et al.
Publicado: (2009)

Kinetics of Water-Induced Amorphous Phase Separation in Amorphous Solid Dispersions via Raman Mapping
por: Krummnow, Adrian, et al.
Publicado: (2023)

Preparation and Characterization of Spherical Amorphous Solid Dispersion with Amphotericin B
por: Mehenni, Lyes, et al.
Publicado: (2018)

Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies
por: Bhujbal, Sonal V., et al.
Publicado: (2021)

Explaining the Release Mechanism of Ritonavir/PVPVA Amorphous Solid Dispersions
por: Krummnow, Adrian, et al.
Publicado: (2022)

Formulation Characterization and Pharmacokinetic Evaluation of Amorphous Solid Dispersions of Dasatinib
por: Dharani, Sathish, et al.
Publicado: (2022)

Advances in the development of amorphous solid dispersions: The role of polymeric carriers
por: Zhang, Jie, et al.
Publicado: (2023)

Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling
por: Asgreen, Camilla, et al.
Publicado: (2020)

Hot-Melt Extruded Amorphous Solid Dispersion for Solubility, Stability, and Bioavailability Enhancement of Telmisartan
por: Giri, Bhupendra Raj, et al.
Publicado: (2021)

Amorphous Solid Dispersions: Role of the Polymer and Its Importance in Physical Stability and In Vitro Performance
por: Shi, Qin, et al.
Publicado: (2022)

Evaluation of Different Thermoanalytical Methods for the Analysis of the Stability of Naproxen-Loaded Amorphous Solid Dispersions
por: Szabó, Edina, et al.
Publicado: (2022)

Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach
por: Larsson, Per, et al.
Publicado: (2017)

Applicability of an Experimental Grade of Hydroxypropyl Methylcellulose Acetate Succinate as a Carrier for Formation of Solid Dispersion with Indomethacin
por: Ueda, Hiroshi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2hiihgjm6ihliodrj3lchn3qq6