A review on the role of mir-16-5p in the carcinogenesis

miR-16-5p is microRNA with important roles in the development of diverse malignancies including neuroblastoma, osteosarcoma, hepatocellular carcinoma, cervical cancer, breast cancer, brain tumors, gastrointestinal cancers, lung cancer and bladder cancer. This miRNA has 22 nucleotides. hsa-miR-16-5p...

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Autores principales: Ghafouri-Fard, Soudeh, Khoshbakht, Tayyebeh, Hussen, Bashdar Mahmud, Abdullah, Sara Tharwat, Taheri, Mohammad, Samadian, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
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Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644515/
https://www.ncbi.nlm.nih.gov/pubmed/36348403
http://dx.doi.org/10.1186/s12935-022-02754-0
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author Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Abdullah, Sara Tharwat
Taheri, Mohammad
Samadian, Mohammad
author_facet Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Abdullah, Sara Tharwat
Taheri, Mohammad
Samadian, Mohammad
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description miR-16-5p is microRNA with important roles in the development of diverse malignancies including neuroblastoma, osteosarcoma, hepatocellular carcinoma, cervical cancer, breast cancer, brain tumors, gastrointestinal cancers, lung cancer and bladder cancer. This miRNA has 22 nucleotides. hsa-miR-16-5p is produced by MIR16-1 gene. First evidence for its participation in the carcinogenesis has been obtained by studies reporting deletion and/or down-regulation of these miRNAs in chronic lymphocytic leukemia. Subsequent studies have shown down-regulation of miR-16-5p in a variety of cancer cell lines and clinical samples. Besides, tumor suppressor role of miR-16-5p has been verified in animal models of different types of cancers. Studies in these models have shown that over-expression of this miRNA or modulation of expression of lncRNAs that sponge this miRNA can block carcinogenic processes. In the current review, we summarize function of miR-16-5p in the development and progression of different cancers.
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spelling pubmed-96445152022-11-15 A review on the role of mir-16-5p in the carcinogenesis Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Hussen, Bashdar Mahmud Abdullah, Sara Tharwat Taheri, Mohammad Samadian, Mohammad Cancer Cell Int Review miR-16-5p is microRNA with important roles in the development of diverse malignancies including neuroblastoma, osteosarcoma, hepatocellular carcinoma, cervical cancer, breast cancer, brain tumors, gastrointestinal cancers, lung cancer and bladder cancer. This miRNA has 22 nucleotides. hsa-miR-16-5p is produced by MIR16-1 gene. First evidence for its participation in the carcinogenesis has been obtained by studies reporting deletion and/or down-regulation of these miRNAs in chronic lymphocytic leukemia. Subsequent studies have shown down-regulation of miR-16-5p in a variety of cancer cell lines and clinical samples. Besides, tumor suppressor role of miR-16-5p has been verified in animal models of different types of cancers. Studies in these models have shown that over-expression of this miRNA or modulation of expression of lncRNAs that sponge this miRNA can block carcinogenic processes. In the current review, we summarize function of miR-16-5p in the development and progression of different cancers. BioMed Central 2022-11-08 /pmc/articles/PMC9644515/ /pubmed/36348403 http://dx.doi.org/10.1186/s12935-022-02754-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Abdullah, Sara Tharwat
Taheri, Mohammad
Samadian, Mohammad
A review on the role of mir-16-5p in the carcinogenesis
title A review on the role of mir-16-5p in the carcinogenesis
title_full A review on the role of mir-16-5p in the carcinogenesis
title_fullStr A review on the role of mir-16-5p in the carcinogenesis
title_full_unstemmed A review on the role of mir-16-5p in the carcinogenesis
title_short A review on the role of mir-16-5p in the carcinogenesis
title_sort review on the role of mir-16-5p in the carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644515/
https://www.ncbi.nlm.nih.gov/pubmed/36348403
http://dx.doi.org/10.1186/s12935-022-02754-0
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