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Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products

BACKGROUND: Clinical CAR T-cell therapy using integrating vector systems represents a promising approach for the treatment of hematological malignancies. Lentiviral and γ-retroviral vectors are the most commonly used vectors in the manufacturing process. However, the integration pattern of these vir...

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Detalles Bibliográficos
Autores principales:	Shao, Lipei, Shi, Rongye, Zhao, Yingdong, Liu, Hui, Lu, Alexander, Ma, Jinxia, Cai, Yihua, Fuksenko, Tatyana, Pelayo, Alejandra, Shah, Nirali N., Kochenderfer, James N., Norberg, Scott M., Hinrichs, Christian, Highfill, Steven L., Somerville, Robert P, Panch, Sandhya R., Jin, Ping, Stroncek, David F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644589/ https://www.ncbi.nlm.nih.gov/pubmed/36348415 http://dx.doi.org/10.1186/s12967-022-03729-5

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