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Assessment of malformations, variations and diameters of vessels forming the circle of Willis – An autopsy study in a non-cerebrovascular cohort
BACKGROUND A PURPOSE: The collateral capacity of the circle of Willis (CoW) may play an important role in the development of ischemic strokes. The occurrence of classical polygon shows wide geographical variations and morphological data on diameters of the Willisian collaterals are scarce. We aimed...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644724/ https://www.ncbi.nlm.nih.gov/pubmed/36406464 http://dx.doi.org/10.1515/tnsci-2022-0253 |
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author | Orosz, László Gyöngyösi, Zoltán Susán, Zsolt Siró, Péter Hoksbergen, Arjan Willem Csiba, László Fülesdi, Béla |
author_facet | Orosz, László Gyöngyösi, Zoltán Susán, Zsolt Siró, Péter Hoksbergen, Arjan Willem Csiba, László Fülesdi, Béla |
author_sort | Orosz, László |
collection | PubMed |
description | BACKGROUND A PURPOSE: The collateral capacity of the circle of Willis (CoW) may play an important role in the development of ischemic strokes. The occurrence of classical polygon shows wide geographical variations and morphological data on diameters of the Willisian collaterals are scarce. We aimed to assess CoW variations and vessel diameters in a Central European cohort. SUBJECTS AND METHODS: CoWs were removed during routine autopsy. The morphological pattern of the circles was recorded. The prepared circles were then put between two glass plates and tightly compressed. The length of the vessels and half of the circumference were measured under a light microscope enabling measurement with an approximation of 0.1 mm. Vessel diameters were calculated from vessel circumference. RESULTS: A total of 110 circles were analysed. Incomplete circles (missing one or two segments of CoW) were found in 25 cases (22.7%). Any forms of anatomical variations were detected in 14 cases (12.7%). When applying the <1 mm diameter threshold for analysis, 36 anterior communicating arteries (32.7%), 53 right posterior communicating arteries (48.2%), 73 left posterior communicating arteries (66.4%) and 18 posterior communicating arteries (16.3%) on both the sides were considered hypoplastic. CONCLUSIONS: In patients without stroke in their history, complete CoW may be present in >60% of the cases. Our diameter data may serve as reference values for the Central-European population. |
format | Online Article Text |
id | pubmed-9644724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-96447242022-11-18 Assessment of malformations, variations and diameters of vessels forming the circle of Willis – An autopsy study in a non-cerebrovascular cohort Orosz, László Gyöngyösi, Zoltán Susán, Zsolt Siró, Péter Hoksbergen, Arjan Willem Csiba, László Fülesdi, Béla Transl Neurosci Research Article BACKGROUND A PURPOSE: The collateral capacity of the circle of Willis (CoW) may play an important role in the development of ischemic strokes. The occurrence of classical polygon shows wide geographical variations and morphological data on diameters of the Willisian collaterals are scarce. We aimed to assess CoW variations and vessel diameters in a Central European cohort. SUBJECTS AND METHODS: CoWs were removed during routine autopsy. The morphological pattern of the circles was recorded. The prepared circles were then put between two glass plates and tightly compressed. The length of the vessels and half of the circumference were measured under a light microscope enabling measurement with an approximation of 0.1 mm. Vessel diameters were calculated from vessel circumference. RESULTS: A total of 110 circles were analysed. Incomplete circles (missing one or two segments of CoW) were found in 25 cases (22.7%). Any forms of anatomical variations were detected in 14 cases (12.7%). When applying the <1 mm diameter threshold for analysis, 36 anterior communicating arteries (32.7%), 53 right posterior communicating arteries (48.2%), 73 left posterior communicating arteries (66.4%) and 18 posterior communicating arteries (16.3%) on both the sides were considered hypoplastic. CONCLUSIONS: In patients without stroke in their history, complete CoW may be present in >60% of the cases. Our diameter data may serve as reference values for the Central-European population. De Gruyter 2022-11-08 /pmc/articles/PMC9644724/ /pubmed/36406464 http://dx.doi.org/10.1515/tnsci-2022-0253 Text en © 2022 László Orosz et al., published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. |
spellingShingle | Research Article Orosz, László Gyöngyösi, Zoltán Susán, Zsolt Siró, Péter Hoksbergen, Arjan Willem Csiba, László Fülesdi, Béla Assessment of malformations, variations and diameters of vessels forming the circle of Willis – An autopsy study in a non-cerebrovascular cohort |
title | Assessment of malformations, variations and diameters of vessels forming the circle of Willis – An autopsy study in a non-cerebrovascular cohort |
title_full | Assessment of malformations, variations and diameters of vessels forming the circle of Willis – An autopsy study in a non-cerebrovascular cohort |
title_fullStr | Assessment of malformations, variations and diameters of vessels forming the circle of Willis – An autopsy study in a non-cerebrovascular cohort |
title_full_unstemmed | Assessment of malformations, variations and diameters of vessels forming the circle of Willis – An autopsy study in a non-cerebrovascular cohort |
title_short | Assessment of malformations, variations and diameters of vessels forming the circle of Willis – An autopsy study in a non-cerebrovascular cohort |
title_sort | assessment of malformations, variations and diameters of vessels forming the circle of willis – an autopsy study in a non-cerebrovascular cohort |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644724/ https://www.ncbi.nlm.nih.gov/pubmed/36406464 http://dx.doi.org/10.1515/tnsci-2022-0253 |
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