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Levels of Influenza A Virus Defective Viral Genomes Determine Pathogenesis in the BALB/c Mouse Model

Defective viral genomes (DVGs), which are generated by the viral polymerase in error during RNA replication, can trigger innate immunity and are implicated in altering the clinical outcome of infection. Here, we investigated the impact of DVGs on innate immunity and pathogenicity in a BALB/c mouse m...

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Detalles Bibliográficos
Autores principales:	Penn, Rebecca, Tregoning, John S., Flight, Katie E., Baillon, Laury, Frise, Rebecca, Goldhill, Daniel H., Johansson, Cecilia, Barclay, Wendy S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645217/ https://www.ncbi.nlm.nih.gov/pubmed/36226985 http://dx.doi.org/10.1128/jvi.01178-22

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