Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors

P-Rex1 and P-Rex2 are guanine-nucleotide exchange factors (GEFs) that activate Rac small GTPases in response to the stimulation of G protein-coupled receptors and phosphoinositide 3-kinase. P-Rex Rac-GEFs regulate the morphology, adhesion and migration of various cell types, as well as reactive oxyg...

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Detalles Bibliográficos
Autores principales: Lawson, CD, Hornigold, K, Pan, D, Niewczas, I, Andrews, S, Clark, J, Welch, HCE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645260/
https://www.ncbi.nlm.nih.gov/pubmed/36342857
http://dx.doi.org/10.1080/21541248.2022.2131313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645260/
https://www.ncbi.nlm.nih.gov/pubmed/36342857
http://dx.doi.org/10.1080/21541248.2022.2131313

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