Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity

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Individuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. However, pr...

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Autores principales: Letsinger, Ayland C., Ward, James M., Fannin, Rick D., Mahapatra, Debabrata, Bridge, Matthew F., Sills, Robert C., Gerrish, Kevin E., Yakel, Jerrel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645428/
https://www.ncbi.nlm.nih.gov/pubmed/36380754
http://dx.doi.org/10.21203/rs.3.rs-2183255/v1
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author Letsinger, Ayland C.
Ward, James M.
Fannin, Rick D.
Mahapatra, Debabrata
Bridge, Matthew F.
Sills, Robert C.
Gerrish, Kevin E.
Yakel, Jerrel L.
author_facet Letsinger, Ayland C.
Ward, James M.
Fannin, Rick D.
Mahapatra, Debabrata
Bridge, Matthew F.
Sills, Robert C.
Gerrish, Kevin E.
Yakel, Jerrel L.
author_sort Letsinger, Ayland C.
collection PubMed
description Individuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. However, pre-exposure to nicotine decreased the likelihood of SARS-CoV-2 RNA expression and pathology in the brain. These results suggest mechanisms involving targets of nicotine could be leveraged to prevent the neurovirulence of SARS-CoV-2.
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spelling pubmed-96454282022-11-15 Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity Letsinger, Ayland C. Ward, James M. Fannin, Rick D. Mahapatra, Debabrata Bridge, Matthew F. Sills, Robert C. Gerrish, Kevin E. Yakel, Jerrel L. Res Sq Article Individuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. However, pre-exposure to nicotine decreased the likelihood of SARS-CoV-2 RNA expression and pathology in the brain. These results suggest mechanisms involving targets of nicotine could be leveraged to prevent the neurovirulence of SARS-CoV-2. American Journal Experts 2022-11-04 /pmc/articles/PMC9645428/ /pubmed/36380754 http://dx.doi.org/10.21203/rs.3.rs-2183255/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Letsinger, Ayland C.
Ward, James M.
Fannin, Rick D.
Mahapatra, Debabrata
Bridge, Matthew F.
Sills, Robert C.
Gerrish, Kevin E.
Yakel, Jerrel L.
Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity
title Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity
title_full Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity
title_fullStr Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity
title_full_unstemmed Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity
title_short Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity
title_sort nicotine exposure decreases likelihood of sars-cov-2 rna expression and neuropathology in the hace2 mouse brain but not moribundity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645428/
https://www.ncbi.nlm.nih.gov/pubmed/36380754
http://dx.doi.org/10.21203/rs.3.rs-2183255/v1
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