Structural and functional basis of mammalian microRNA biogenesis by Dicer

MicroRNA (miRNA) and RNA interference (RNAi) pathways rely on small RNAs produced by Dicer endonucleases. Mammalian Dicer primarily supports the essential gene-regulating miRNA pathway, but how it is specifically adapted to miRNA biogenesis is unknown. We show that the adaptation entails a unique st...

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Detalles Bibliográficos
Autores principales: Zapletal, David, Taborska, Eliska, Pasulka, Josef, Malik, Radek, Kubicek, Karel, Zanova, Martina, Much, Christian, Sebesta, Marek, Buccheri, Valeria, Horvat, Filip, Jenickova, Irena, Prochazkova, Michaela, Prochazka, Jan, Pinkas, Matyas, Novacek, Jiri, Joseph, Diego F., Sedlacek, Radislav, Bernecky, Carrie, O’Carroll, Dónal, Stefl, Richard, Svoboda, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645528/
https://www.ncbi.nlm.nih.gov/pubmed/36332606
http://dx.doi.org/10.1016/j.molcel.2022.10.010

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