Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages

The emergence of Plasmodium falciparum parasite resistance to dihydroartemisinin + piperaquine (PPQ) in Southeast Asia threatens plans to increase the global use of this first-line antimalarial combination. High-level PPQ resistance appears to be mediated primarily by novel mutations in the P. falci...

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Detalles Bibliográficos
Autores principales: Okombo, John, Mok, Sachel, Qahash, Tarrick, Yeo, Tomas, Bath, Jade, Orchard, Lindsey M., Owens, Edward, Koo, Imhoi, Albert, Istvan, Llinás, Manuel, Fidock, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645663/
https://www.ncbi.nlm.nih.gov/pubmed/36306287
http://dx.doi.org/10.1371/journal.ppat.1010926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645663/
https://www.ncbi.nlm.nih.gov/pubmed/36306287
http://dx.doi.org/10.1371/journal.ppat.1010926

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