DNA replication initiation shapes the mutational landscape and expression of the human genome

The interplay between active biological processes and DNA repair is central to mutagenesis. Here, we show that the ubiquitous process of replication initiation is mutagenic, leaving a specific mutational footprint at thousands of early and efficient replication origins. The observed mutational patte...

Descripción completa

Detalles Bibliográficos
Autores principales: Murat, Pierre, Perez, Consuelo, Crisp, Alastair, van Eijk, Patrick, Reed, Simon H., Guilbaud, Guillaume, Sale, Julian E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645720/
https://www.ncbi.nlm.nih.gov/pubmed/36351018
http://dx.doi.org/10.1126/sciadv.add3686

Ejemplares similares

Ejemplares similares