Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma

A 52-year-old man presented with palatine tonsillar swelling caused by follicular lymphoma. His tumor burden was low, but exacerbation of snoring and dysphagia was observed. Considering the first wave of coronavirus disease 2019 (COVID-19) pandemic, he received palliative 4-Gy irradiation to the ton...

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Autores principales: Togitani, Kazuto, Asagiri, Tadashi, Iguchi, Mitsuko, Igawa, Takuro, Yoshino, Tadashi, Kojima, Kensuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646336/
https://www.ncbi.nlm.nih.gov/pubmed/35314548
http://dx.doi.org/10.2169/internalmedicine.8968-21
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author Togitani, Kazuto
Asagiri, Tadashi
Iguchi, Mitsuko
Igawa, Takuro
Yoshino, Tadashi
Kojima, Kensuke
author_facet Togitani, Kazuto
Asagiri, Tadashi
Iguchi, Mitsuko
Igawa, Takuro
Yoshino, Tadashi
Kojima, Kensuke
author_sort Togitani, Kazuto
collection PubMed
description A 52-year-old man presented with palatine tonsillar swelling caused by follicular lymphoma. His tumor burden was low, but exacerbation of snoring and dysphagia was observed. Considering the first wave of coronavirus disease 2019 (COVID-19) pandemic, he received palliative 4-Gy irradiation to the tonsils in 2 fractions, which induced partial regression of tonsillar swellings and eradication of the circulating lymphoma cells. We suggest that low-dose radiotherapy triggered an abscopal effect of lymphoma, which allowed the patient time to receive COVID-19 vaccination before starting immunosuppressive chemo-immunotherapy.
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spelling pubmed-96463362022-11-18 Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma Togitani, Kazuto Asagiri, Tadashi Iguchi, Mitsuko Igawa, Takuro Yoshino, Tadashi Kojima, Kensuke Intern Med Case Report A 52-year-old man presented with palatine tonsillar swelling caused by follicular lymphoma. His tumor burden was low, but exacerbation of snoring and dysphagia was observed. Considering the first wave of coronavirus disease 2019 (COVID-19) pandemic, he received palliative 4-Gy irradiation to the tonsils in 2 fractions, which induced partial regression of tonsillar swellings and eradication of the circulating lymphoma cells. We suggest that low-dose radiotherapy triggered an abscopal effect of lymphoma, which allowed the patient time to receive COVID-19 vaccination before starting immunosuppressive chemo-immunotherapy. The Japanese Society of Internal Medicine 2022-03-19 2022-10-15 /pmc/articles/PMC9646336/ /pubmed/35314548 http://dx.doi.org/10.2169/internalmedicine.8968-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Togitani, Kazuto
Asagiri, Tadashi
Iguchi, Mitsuko
Igawa, Takuro
Yoshino, Tadashi
Kojima, Kensuke
Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma
title Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma
title_full Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma
title_fullStr Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma
title_full_unstemmed Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma
title_short Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma
title_sort systemic abscopal effect of low-dose radiotherapy (2 gy ×2) against palatine tonsil follicular lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646336/
https://www.ncbi.nlm.nih.gov/pubmed/35314548
http://dx.doi.org/10.2169/internalmedicine.8968-21
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