Adult-onset Still's Disease during Pregnancy Treated with Tocilizumab

A 28-year-old woman exhibited a spiking fever, arthritis, and liver disfunction when she was 22 weeks pregnant. She was diagnosed with adult-onset Still's disease (AOSD). As her condition was resistant to corticosteroid therapy, tocilizumab (TCZ) was selected. The TCZ treatment was effective, a...

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Detalles Bibliográficos
Autores principales: Imaizumi, Chihiro, Saito, Masaya, Abe, Fumito, Kaga, Hajime, Saito, Ayano, Nara, Mizuho, Kameyama, Saeko, Miura, Hiroshi, Ogasawara, Hitoshi, Hirakawa, Takeo, Mizunuma, Makito, Satoh, Makiko, Komatsuda, Atsushi, Terada, Yukihiro, Takahashi, Naoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646338/
https://www.ncbi.nlm.nih.gov/pubmed/35283384
http://dx.doi.org/10.2169/internalmedicine.8886-21
Descripción
Sumario:A 28-year-old woman exhibited a spiking fever, arthritis, and liver disfunction when she was 22 weeks pregnant. She was diagnosed with adult-onset Still's disease (AOSD). As her condition was resistant to corticosteroid therapy, tocilizumab (TCZ) was selected. The TCZ treatment was effective, and she delivered a healthy child while receiving TCZ treatment. Cases in which AOSD first arises during pregnancy are rare, and there have been no reports of TCZ treatment for AOSD being initiated during pregnancy. Although the safety of TCZ treatment during pregnancy has not been established, it may be effective against severe AOSD that develops during pregnancy.

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