Acute Oropharyngeal Palsy Following Bilateral Adie's Tonic Pupils Associated with Anti-GT1a and GQ1b IgG Antibodies

A 36-year-old man was admitted to our hospital with complaints of dysphagia and photophobia. A neurological examination showed oropharyngeal palsy and bilateral mydriasis with loss of light reflexes in the absence of external ophthalmoplegia. Bilateral pupils were supersensitive to pilocarpine 0.1%,...

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Autores principales: Murakami, Keishu, Kajimoto, Yoshinori, Ito, Hidefumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646358/
https://www.ncbi.nlm.nih.gov/pubmed/35370231
http://dx.doi.org/10.2169/internalmedicine.8416-21
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author Murakami, Keishu
Kajimoto, Yoshinori
Ito, Hidefumi
author_facet Murakami, Keishu
Kajimoto, Yoshinori
Ito, Hidefumi
author_sort Murakami, Keishu
collection PubMed
description A 36-year-old man was admitted to our hospital with complaints of dysphagia and photophobia. A neurological examination showed oropharyngeal palsy and bilateral mydriasis with loss of light reflexes in the absence of external ophthalmoplegia. Bilateral pupils were supersensitive to pilocarpine 0.1%, which was compatible with Adie's tonic pupils. Serum IgG reacted with GQ1b, GT1a, GalNAc-GD1a, and GD3. Intravenous high-dose immunoglobulin therapy improved his neurological symptoms within three weeks. To our knowledge, there is no medical literature describing acute oropharyngeal palsy with Adie's tonic pupils. We recommend evaluating antiganglioside antibodies to clarify the cause of oropharyngeal palsy and Adie's tonic pupils.
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spelling pubmed-96463582022-11-18 Acute Oropharyngeal Palsy Following Bilateral Adie's Tonic Pupils Associated with Anti-GT1a and GQ1b IgG Antibodies Murakami, Keishu Kajimoto, Yoshinori Ito, Hidefumi Intern Med Case Report A 36-year-old man was admitted to our hospital with complaints of dysphagia and photophobia. A neurological examination showed oropharyngeal palsy and bilateral mydriasis with loss of light reflexes in the absence of external ophthalmoplegia. Bilateral pupils were supersensitive to pilocarpine 0.1%, which was compatible with Adie's tonic pupils. Serum IgG reacted with GQ1b, GT1a, GalNAc-GD1a, and GD3. Intravenous high-dose immunoglobulin therapy improved his neurological symptoms within three weeks. To our knowledge, there is no medical literature describing acute oropharyngeal palsy with Adie's tonic pupils. We recommend evaluating antiganglioside antibodies to clarify the cause of oropharyngeal palsy and Adie's tonic pupils. The Japanese Society of Internal Medicine 2022-04-02 2022-10-15 /pmc/articles/PMC9646358/ /pubmed/35370231 http://dx.doi.org/10.2169/internalmedicine.8416-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Murakami, Keishu
Kajimoto, Yoshinori
Ito, Hidefumi
Acute Oropharyngeal Palsy Following Bilateral Adie's Tonic Pupils Associated with Anti-GT1a and GQ1b IgG Antibodies
title Acute Oropharyngeal Palsy Following Bilateral Adie's Tonic Pupils Associated with Anti-GT1a and GQ1b IgG Antibodies
title_full Acute Oropharyngeal Palsy Following Bilateral Adie's Tonic Pupils Associated with Anti-GT1a and GQ1b IgG Antibodies
title_fullStr Acute Oropharyngeal Palsy Following Bilateral Adie's Tonic Pupils Associated with Anti-GT1a and GQ1b IgG Antibodies
title_full_unstemmed Acute Oropharyngeal Palsy Following Bilateral Adie's Tonic Pupils Associated with Anti-GT1a and GQ1b IgG Antibodies
title_short Acute Oropharyngeal Palsy Following Bilateral Adie's Tonic Pupils Associated with Anti-GT1a and GQ1b IgG Antibodies
title_sort acute oropharyngeal palsy following bilateral adie's tonic pupils associated with anti-gt1a and gq1b igg antibodies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646358/
https://www.ncbi.nlm.nih.gov/pubmed/35370231
http://dx.doi.org/10.2169/internalmedicine.8416-21
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AT kajimotoyoshinori acuteoropharyngealpalsyfollowingbilateraladiestonicpupilsassociatedwithantigt1aandgq1biggantibodies
AT itohidefumi acuteoropharyngealpalsyfollowingbilateraladiestonicpupilsassociatedwithantigt1aandgq1biggantibodies

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