Cargando…
The Prevalence, Incidence, and Risk Factors for HIV Among Female Sex Workers—A Cohort Being Prepared for a Phase IIb HIV Vaccine Trial in Dar es Salaam, Tanzania
A cohort of female sex workers (FSWs) was established to determine HIV prevalence and incidence, and associated factors in preparation for a phase IIb HIV vaccine and pre-exposure prophylaxis trial (PrEPVacc). SETTING: A cohort of FSWs in Dar es Salaam, Tanzania. METHODS: FSWs aged 18–45 years were...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JAIDS Journal of Acquired Immune Deficiency Syndromes
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646411/ https://www.ncbi.nlm.nih.gov/pubmed/36126184 http://dx.doi.org/10.1097/QAI.0000000000003097 |
_version_ | 1784827160285937664 |
---|---|
author | Faini, Diana Msafiri, Frank Munseri, Patricia Bakari, Muhammad Lyamuya, Eligius Sandström, Eric Biberfeld, Gunnel Nilsson, Charlotta Hanson, Claudia Aboud, Said |
author_facet | Faini, Diana Msafiri, Frank Munseri, Patricia Bakari, Muhammad Lyamuya, Eligius Sandström, Eric Biberfeld, Gunnel Nilsson, Charlotta Hanson, Claudia Aboud, Said |
author_sort | Faini, Diana |
collection | PubMed |
description | A cohort of female sex workers (FSWs) was established to determine HIV prevalence and incidence, and associated factors in preparation for a phase IIb HIV vaccine and pre-exposure prophylaxis trial (PrEPVacc). SETTING: A cohort of FSWs in Dar es Salaam, Tanzania. METHODS: FSWs aged 18–45 years were recruited using a respondent-driven sampling method. Social demographic data, HIV risk behavioral assessments, and blood samples for testing of HIV, syphilis, hepatitis B (HBV), and hepatitis C (HCV) infections were collected at baseline and then at 3, 6, 9, and 12 months. Poisson regressions were used to estimate the prevalence ratios for factors associated with HIV prevalence and to estimate the 12-month HIV incidence rate. RESULTS: Between October and December 2018, a total of 773 FSWs were screened for eligibility and 700 were enrolled. The baseline prevalence of HIV, syphilis, HBV, and HCV was 7.6%, 1.2%, 1.7%, and 1.0%, respectively. HIV prevalence was associated with older age, using illicit drugs, and being infected with syphilis, HBV, or HCV. Attendance at 12 months was 80% (562/700). Twenty-one FSWs seroconverted during follow-up, giving a 12-month HIV incidence rate of 3.45 per 100 person-years at risk (95% CI; 2.25–5.28/100 person-years at risk). The HIV incidence rate was higher among FSWs aged 18–24 years, FSWs who used drugs, and those diagnosed with syphilis, HBV, or HCV. CONCLUSION: The high HIV incidence rate and retention rate among FSWs enrolled into the cohort demonstrate that this population is suitable for participation in HIV prevention trials. |
format | Online Article Text |
id | pubmed-9646411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | JAIDS Journal of Acquired Immune Deficiency Syndromes |
record_format | MEDLINE/PubMed |
spelling | pubmed-96464112022-11-14 The Prevalence, Incidence, and Risk Factors for HIV Among Female Sex Workers—A Cohort Being Prepared for a Phase IIb HIV Vaccine Trial in Dar es Salaam, Tanzania Faini, Diana Msafiri, Frank Munseri, Patricia Bakari, Muhammad Lyamuya, Eligius Sandström, Eric Biberfeld, Gunnel Nilsson, Charlotta Hanson, Claudia Aboud, Said J Acquir Immune Defic Syndr Epidemiology A cohort of female sex workers (FSWs) was established to determine HIV prevalence and incidence, and associated factors in preparation for a phase IIb HIV vaccine and pre-exposure prophylaxis trial (PrEPVacc). SETTING: A cohort of FSWs in Dar es Salaam, Tanzania. METHODS: FSWs aged 18–45 years were recruited using a respondent-driven sampling method. Social demographic data, HIV risk behavioral assessments, and blood samples for testing of HIV, syphilis, hepatitis B (HBV), and hepatitis C (HCV) infections were collected at baseline and then at 3, 6, 9, and 12 months. Poisson regressions were used to estimate the prevalence ratios for factors associated with HIV prevalence and to estimate the 12-month HIV incidence rate. RESULTS: Between October and December 2018, a total of 773 FSWs were screened for eligibility and 700 were enrolled. The baseline prevalence of HIV, syphilis, HBV, and HCV was 7.6%, 1.2%, 1.7%, and 1.0%, respectively. HIV prevalence was associated with older age, using illicit drugs, and being infected with syphilis, HBV, or HCV. Attendance at 12 months was 80% (562/700). Twenty-one FSWs seroconverted during follow-up, giving a 12-month HIV incidence rate of 3.45 per 100 person-years at risk (95% CI; 2.25–5.28/100 person-years at risk). The HIV incidence rate was higher among FSWs aged 18–24 years, FSWs who used drugs, and those diagnosed with syphilis, HBV, or HCV. CONCLUSION: The high HIV incidence rate and retention rate among FSWs enrolled into the cohort demonstrate that this population is suitable for participation in HIV prevention trials. JAIDS Journal of Acquired Immune Deficiency Syndromes 2022-12-15 2022-09-20 /pmc/articles/PMC9646411/ /pubmed/36126184 http://dx.doi.org/10.1097/QAI.0000000000003097 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Epidemiology Faini, Diana Msafiri, Frank Munseri, Patricia Bakari, Muhammad Lyamuya, Eligius Sandström, Eric Biberfeld, Gunnel Nilsson, Charlotta Hanson, Claudia Aboud, Said The Prevalence, Incidence, and Risk Factors for HIV Among Female Sex Workers—A Cohort Being Prepared for a Phase IIb HIV Vaccine Trial in Dar es Salaam, Tanzania |
title | The Prevalence, Incidence, and Risk Factors for HIV Among Female Sex Workers—A Cohort Being Prepared for a Phase IIb HIV Vaccine Trial in Dar es Salaam, Tanzania |
title_full | The Prevalence, Incidence, and Risk Factors for HIV Among Female Sex Workers—A Cohort Being Prepared for a Phase IIb HIV Vaccine Trial in Dar es Salaam, Tanzania |
title_fullStr | The Prevalence, Incidence, and Risk Factors for HIV Among Female Sex Workers—A Cohort Being Prepared for a Phase IIb HIV Vaccine Trial in Dar es Salaam, Tanzania |
title_full_unstemmed | The Prevalence, Incidence, and Risk Factors for HIV Among Female Sex Workers—A Cohort Being Prepared for a Phase IIb HIV Vaccine Trial in Dar es Salaam, Tanzania |
title_short | The Prevalence, Incidence, and Risk Factors for HIV Among Female Sex Workers—A Cohort Being Prepared for a Phase IIb HIV Vaccine Trial in Dar es Salaam, Tanzania |
title_sort | prevalence, incidence, and risk factors for hiv among female sex workers—a cohort being prepared for a phase iib hiv vaccine trial in dar es salaam, tanzania |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646411/ https://www.ncbi.nlm.nih.gov/pubmed/36126184 http://dx.doi.org/10.1097/QAI.0000000000003097 |
work_keys_str_mv | AT fainidiana theprevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT msafirifrank theprevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT munseripatricia theprevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT bakarimuhammad theprevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT lyamuyaeligius theprevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT sandstromeric theprevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT biberfeldgunnel theprevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT nilssoncharlotta theprevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT hansonclaudia theprevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT aboudsaid theprevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT fainidiana prevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT msafirifrank prevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT munseripatricia prevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT bakarimuhammad prevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT lyamuyaeligius prevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT sandstromeric prevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT biberfeldgunnel prevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT nilssoncharlotta prevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT hansonclaudia prevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania AT aboudsaid prevalenceincidenceandriskfactorsforhivamongfemalesexworkersacohortbeingpreparedforaphaseiibhivvaccinetrialindaressalaamtanzania |