High Unreported Mortality in Children and Youth (<25 Years) Living With HIV Who Were Lost to Care From Antiretroviral Therapy Programs in Southern Africa: Results From a Multicountry Tracing Study

Antiretroviral therapy program mortality maybe underestimated if deceased patients are misclassified as lost. METHODS: We used two-stage inverse probability weighting to account for probability of being: sampled for tracing and found by the tracer. RESULTS: Among 680 children and youth aged <25 y...

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Detalles Bibliográficos
Autores principales: Nyakato, Patience, Christ, Benedikt, Anderegg, Nanina, Muhairwe, Josephine, Jefferys, Laura, van Dijk, Janneke, Vinikoor, Michael J., van Lettow, Monique, Chimbetete, Cleophas, Phiri, Sam J., Egger, Matthias, Ballif, Marie, Yiannoutsos, Constantin T., Schomaker, Michael, Kassanjee, Reshma, Davies, Mary-Ann, Cornell, Morna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JAIDS Journal of Acquired Immune Deficiency Syndromes 2022
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646412/
https://www.ncbi.nlm.nih.gov/pubmed/36099024
http://dx.doi.org/10.1097/QAI.0000000000003090
Descripción
Sumario:Antiretroviral therapy program mortality maybe underestimated if deceased patients are misclassified as lost. METHODS: We used two-stage inverse probability weighting to account for probability of being: sampled for tracing and found by the tracer. RESULTS: Among 680 children and youth aged <25 years on antiretroviral therapy who were lost and traced in Southern Africa between October 2017 and November 2019, estimated mortality was high at 9.1% (62/680). After adjusting for measured covariates and within-site clustering, mortality remained lower for young adults aged 20–24 years compared with infants aged <2 years [adjusted hazard ratio: 0.40 (95% confidence interval: 0.31 to 0.51)]. CONCLUSIONS: Our study confirms high unreported mortality in children and youth who are lost and the need for tracing to assess vital status among those who are lost to accurately report on program mortality.

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