Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression

ATR kinase is a central regulator of the DNA damage response (DDR) and cell cycle checkpoints. ATR kinase inhibitors (ATRi’s) combine with radiation to generate CD8(+) T cell-dependent responses in mouse models of cancer. We show that ATRi’s induce cyclin-dependent kinase 1 (CDK1)-dependent origin f...

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Detalles Bibliográficos
Autores principales: Sugitani, Norie, Vendetti, Frank P., Cipriano, Andrew J., Pandya, Pinakin, Deppas, Joshua J., Moiseeva, Tatiana N., Schamus-Haynes, Sandra, Wang, Yiyang, Palmer, Drake, Osmanbeyoglu, Hatice U., Bostwick, Anna, Snyder, Nathaniel W., Gong, Yi-Nan, Aird, Katherine M., Delgoffe, Greg M., Beumer, Jan H., Bakkenist, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646445/
https://www.ncbi.nlm.nih.gov/pubmed/36130512
http://dx.doi.org/10.1016/j.celrep.2022.111371

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