Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases

Proteome-wide Mendelian randomization (MR) shows value in prioritizing drug targets in Europeans but with limited evidence in other ancestries. Here, we present a multi-ancestry proteome-wide MR analysis based on cross-population data from the Global Biobank Meta-analysis Initiative (GBMI). We estim...

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Detalles Bibliográficos
Autores principales: Zhao, Huiling, Rasheed, Humaria, Nøst, Therese Haugdahl, Cho, Yoonsu, Liu, Yi, Bhatta, Laxmi, Bhattacharya, Arjun, Hemani, Gibran, Davey Smith, George, Brumpton, Ben Michael, Zhou, Wei, Neale, Benjamin M., Gaunt, Tom R., Zheng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646482/
https://www.ncbi.nlm.nih.gov/pubmed/36388766
http://dx.doi.org/10.1016/j.xgen.2022.100195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646482/
https://www.ncbi.nlm.nih.gov/pubmed/36388766
http://dx.doi.org/10.1016/j.xgen.2022.100195

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