Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we present SigProfilerExtractor, an automated tool for de novo extraction of mutational signatures, and benchmark it against another 13 bioinformatics tools by using 34 scenarios encompassing 2,500 simulated signatu...

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Detalles Bibliográficos
Autores principales: Islam, S.M. Ashiqul, Díaz-Gay, Marcos, Wu, Yang, Barnes, Mark, Vangara, Raviteja, Bergstrom, Erik N., He, Yudou, Vella, Mike, Wang, Jingwei, Teague, Jon W., Clapham, Peter, Moody, Sarah, Senkin, Sergey, Li, Yun Rose, Riva, Laura, Zhang, Tongwu, Gruber, Andreas J., Steele, Christopher D., Otlu, Burçak, Khandekar, Azhar, Abbasi, Ammal, Humphreys, Laura, Syulyukina, Natalia, Brady, Samuel W., Alexandrov, Boian S., Pillay, Nischalan, Zhang, Jinghui, Adams, David J., Martincorena, Iñigo, Wedge, David C., Landi, Maria Teresa, Brennan, Paul, Stratton, Michael R., Rozen, Steven G., Alexandrov, Ludmil B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Technology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646490/
https://www.ncbi.nlm.nih.gov/pubmed/36388765
http://dx.doi.org/10.1016/j.xgen.2022.100179

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