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A mini-review: environmental and metabolic factors affecting aminoglycoside efficacy

Following the discovery of streptomycin from Streptomyces griseus in the 1940s by Selman Waksman and colleagues, aminoglycosides were first used to treat tuberculosis and then numerous derivatives have since been used to combat a wide variety of bacterial infections. These bactericidal antibiotics w...

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Autores principales: Webster, Calum M., Shepherd, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646598/
https://www.ncbi.nlm.nih.gov/pubmed/36350431
http://dx.doi.org/10.1007/s11274-022-03445-8
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author Webster, Calum M.
Shepherd, Mark
author_facet Webster, Calum M.
Shepherd, Mark
author_sort Webster, Calum M.
collection PubMed
description Following the discovery of streptomycin from Streptomyces griseus in the 1940s by Selman Waksman and colleagues, aminoglycosides were first used to treat tuberculosis and then numerous derivatives have since been used to combat a wide variety of bacterial infections. These bactericidal antibiotics were used as first-line treatments for several decades but were largely replaced by ß-lactams and fluoroquinolones in the 1980s, although widespread emergence of antibiotic-resistance has led to renewed interest in aminoglycosides. The primary site of action for aminoglycosides is the 30 S ribosomal subunit where they disrupt protein translation, which contributes to widespread cellular damage through a number of secondary effects including rapid uptake of aminoglycosides via elevated proton-motive force (PMF), membrane damage and breakdown, oxidative stress, and hyperpolarisation of the membrane. Several factors associated with aminoglycoside entry have been shown to impact upon bacterial killing, and more recent work has revealed a complex relationship between metabolic states and the efficacy of different aminoglycosides. Hence, it is imperative to consider the environmental conditions and bacterial physiology and how this can impact upon aminoglycoside entry and potency. This mini-review seeks to discuss recent advances in this area and how this might affect the future use of aminoglycosides.
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spelling pubmed-96465982022-11-15 A mini-review: environmental and metabolic factors affecting aminoglycoside efficacy Webster, Calum M. Shepherd, Mark World J Microbiol Biotechnol Review Following the discovery of streptomycin from Streptomyces griseus in the 1940s by Selman Waksman and colleagues, aminoglycosides were first used to treat tuberculosis and then numerous derivatives have since been used to combat a wide variety of bacterial infections. These bactericidal antibiotics were used as first-line treatments for several decades but were largely replaced by ß-lactams and fluoroquinolones in the 1980s, although widespread emergence of antibiotic-resistance has led to renewed interest in aminoglycosides. The primary site of action for aminoglycosides is the 30 S ribosomal subunit where they disrupt protein translation, which contributes to widespread cellular damage through a number of secondary effects including rapid uptake of aminoglycosides via elevated proton-motive force (PMF), membrane damage and breakdown, oxidative stress, and hyperpolarisation of the membrane. Several factors associated with aminoglycoside entry have been shown to impact upon bacterial killing, and more recent work has revealed a complex relationship between metabolic states and the efficacy of different aminoglycosides. Hence, it is imperative to consider the environmental conditions and bacterial physiology and how this can impact upon aminoglycoside entry and potency. This mini-review seeks to discuss recent advances in this area and how this might affect the future use of aminoglycosides. Springer Netherlands 2022-11-09 2023 /pmc/articles/PMC9646598/ /pubmed/36350431 http://dx.doi.org/10.1007/s11274-022-03445-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Webster, Calum M.
Shepherd, Mark
A mini-review: environmental and metabolic factors affecting aminoglycoside efficacy
title A mini-review: environmental and metabolic factors affecting aminoglycoside efficacy
title_full A mini-review: environmental and metabolic factors affecting aminoglycoside efficacy
title_fullStr A mini-review: environmental and metabolic factors affecting aminoglycoside efficacy
title_full_unstemmed A mini-review: environmental and metabolic factors affecting aminoglycoside efficacy
title_short A mini-review: environmental and metabolic factors affecting aminoglycoside efficacy
title_sort mini-review: environmental and metabolic factors affecting aminoglycoside efficacy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646598/
https://www.ncbi.nlm.nih.gov/pubmed/36350431
http://dx.doi.org/10.1007/s11274-022-03445-8
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