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Network pharmacology and molecular docking reveal the mechanism of Angelica dahurica against Osteosarcoma

Osteosarcoma (OS) is a malignant bone tumor of mesenchymal origin. Angelica dahurica is a typical traditional Chinese herb. Angelica dahurica is used in the treatment of a variety of tumors. However, the studies of Angelica dahurica for OS have not been reported. To investigate Angelica dahurica’s p...

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Autores principales: Zhang, Yafang, Li, Zhehong, Wei, Junqiang, Kong, Lingwei, Song, Mingze, Zhang, Yange, Xiao, Xiangyu, Cao, Haiying, Jin, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646661/
https://www.ncbi.nlm.nih.gov/pubmed/36343039
http://dx.doi.org/10.1097/MD.0000000000031055
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author Zhang, Yafang
Li, Zhehong
Wei, Junqiang
Kong, Lingwei
Song, Mingze
Zhang, Yange
Xiao, Xiangyu
Cao, Haiying
Jin, Yu
author_facet Zhang, Yafang
Li, Zhehong
Wei, Junqiang
Kong, Lingwei
Song, Mingze
Zhang, Yange
Xiao, Xiangyu
Cao, Haiying
Jin, Yu
author_sort Zhang, Yafang
collection PubMed
description Osteosarcoma (OS) is a malignant bone tumor of mesenchymal origin. Angelica dahurica is a typical traditional Chinese herb. Angelica dahurica is used in the treatment of a variety of tumors. However, the studies of Angelica dahurica for OS have not been reported. To investigate Angelica dahurica’s potential mechanism of action in the treatment of OS, we used network pharmacology and molecular docking methods in this study. Of which the network pharmacology includes the collection of active ingredients of Angelica dahurica, the collection of predicted targets of Angelica dahurica and predicted targets of OS, the analysis of therapeutic targets of Angelica dahurica, gene ontology (GO) enrichment, and Kyoto encyclopedia of genes and genomes (KEGG) enrichment. The Venn plot performance showed that there were 225 predicted targets of Angelica dahurica for the treatment of OS. The therapeutic targets enrichment analysis results showed that Angelica dahurica treated OS through multiple targets and pathways. Angelica dahurica could affect OS’s proliferation, apoptosis, migration, infiltration, and angiogenesis through a signaling network formed by pivotal genes crosstalking numerous signaling pathways. In addition, molecular docking results showed that sen-byakangelicol, beta-sitosterol, and Prangenin, have a relatively high potential to become a treatment for patients with OS and improve 5-year survival in OS patients. We used network pharmacology and molecular docking methods to predict the active ingredients and significant targets of Angelica dahurica for the treatment of OS and, to a certain extent, elucidated the potential molecular mechanism of Angelica dahurica in the treatment of OS. This study provided a theoretical basis for Angelica dahurica in the treatment of OS.
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spelling pubmed-96466612022-11-14 Network pharmacology and molecular docking reveal the mechanism of Angelica dahurica against Osteosarcoma Zhang, Yafang Li, Zhehong Wei, Junqiang Kong, Lingwei Song, Mingze Zhang, Yange Xiao, Xiangyu Cao, Haiying Jin, Yu Medicine (Baltimore) 4200 Osteosarcoma (OS) is a malignant bone tumor of mesenchymal origin. Angelica dahurica is a typical traditional Chinese herb. Angelica dahurica is used in the treatment of a variety of tumors. However, the studies of Angelica dahurica for OS have not been reported. To investigate Angelica dahurica’s potential mechanism of action in the treatment of OS, we used network pharmacology and molecular docking methods in this study. Of which the network pharmacology includes the collection of active ingredients of Angelica dahurica, the collection of predicted targets of Angelica dahurica and predicted targets of OS, the analysis of therapeutic targets of Angelica dahurica, gene ontology (GO) enrichment, and Kyoto encyclopedia of genes and genomes (KEGG) enrichment. The Venn plot performance showed that there were 225 predicted targets of Angelica dahurica for the treatment of OS. The therapeutic targets enrichment analysis results showed that Angelica dahurica treated OS through multiple targets and pathways. Angelica dahurica could affect OS’s proliferation, apoptosis, migration, infiltration, and angiogenesis through a signaling network formed by pivotal genes crosstalking numerous signaling pathways. In addition, molecular docking results showed that sen-byakangelicol, beta-sitosterol, and Prangenin, have a relatively high potential to become a treatment for patients with OS and improve 5-year survival in OS patients. We used network pharmacology and molecular docking methods to predict the active ingredients and significant targets of Angelica dahurica for the treatment of OS and, to a certain extent, elucidated the potential molecular mechanism of Angelica dahurica in the treatment of OS. This study provided a theoretical basis for Angelica dahurica in the treatment of OS. Lippincott Williams & Wilkins 2022-11-04 /pmc/articles/PMC9646661/ /pubmed/36343039 http://dx.doi.org/10.1097/MD.0000000000031055 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 4200
Zhang, Yafang
Li, Zhehong
Wei, Junqiang
Kong, Lingwei
Song, Mingze
Zhang, Yange
Xiao, Xiangyu
Cao, Haiying
Jin, Yu
Network pharmacology and molecular docking reveal the mechanism of Angelica dahurica against Osteosarcoma
title Network pharmacology and molecular docking reveal the mechanism of Angelica dahurica against Osteosarcoma
title_full Network pharmacology and molecular docking reveal the mechanism of Angelica dahurica against Osteosarcoma
title_fullStr Network pharmacology and molecular docking reveal the mechanism of Angelica dahurica against Osteosarcoma
title_full_unstemmed Network pharmacology and molecular docking reveal the mechanism of Angelica dahurica against Osteosarcoma
title_short Network pharmacology and molecular docking reveal the mechanism of Angelica dahurica against Osteosarcoma
title_sort network pharmacology and molecular docking reveal the mechanism of angelica dahurica against osteosarcoma
topic 4200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646661/
https://www.ncbi.nlm.nih.gov/pubmed/36343039
http://dx.doi.org/10.1097/MD.0000000000031055
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