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Gradient-based parameter optimization method to determine membrane ionic current composition in human induced pluripotent stem cell-derived cardiomyocytes

Premature cardiac myocytes derived from human induced pluripotent stem cells (hiPSC-CMs) show heterogeneous action potentials (APs), probably due to different expression patterns of membrane ionic currents. We developed a method for determining expression patterns of functional channels in terms of...

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Detalles Bibliográficos
Autores principales:	Kohjitani, Hirohiko, Koda, Shigeya, Himeno, Yukiko, Makiyama, Takeru, Yamamoto, Yuta, Yoshinaga, Daisuke, Wuriyanghai, Yimin, Kashiwa, Asami, Toyoda, Futoshi, Zhang, Yixin, Amano, Akira, Noma, Akinori, Kimura, Takeshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646722/ https://www.ncbi.nlm.nih.gov/pubmed/36351955 http://dx.doi.org/10.1038/s41598-022-23398-0

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