Recognition motifs for importin 4 [(L)PPRS(G/P)P] and importin 5 [KP(K/Y)LV] binding, identified by bio-informatic simulation and experimental in vitro validation

Nuclear translocation of large proteins is mediated through karyopherins, carrier proteins recognizing specific motifs of cargo proteins, known as nuclear localization signals (NLS). However, only few NLS signals have been reported until now. In the present work, NLS signals for Importins 4 and 5 we...

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Detalles Bibliográficos
Autores principales: Panagiotopoulos, Athanasios A., Kalyvianaki, Konstantina, Tsodoulou, Paraskevi K., Darivianaki, Maria N., Dellis, Dimitris, Notas, George, Daskalakis, Vangelis, Theodoropoulos, Panayiotis A., Panagiotidis, Christos Α., Castanas, Elias, Kampa, Marilena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646746/
https://www.ncbi.nlm.nih.gov/pubmed/36382187
http://dx.doi.org/10.1016/j.csbj.2022.10.015

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