An allosteric modulator activates BK channels by perturbing coupling between Ca(2+) binding and pore opening

BK type Ca(2+)-activated K(+) channels activate in response to both voltage and Ca(2+). The membrane-spanning voltage sensor domain (VSD) activation and Ca(2+) binding to the cytosolic tail domain (CTD) open the pore across the membrane, but the mechanisms that couple VSD activation and Ca(2+) bindi...

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Detalles Bibliográficos
Autores principales: Zhang, Guohui, Xu, Xianjin, Jia, Zhiguang, Geng, Yanyan, Liang, Hongwu, Shi, Jingyi, Marras, Martina, Abella, Carlota, Magleby, Karl L., Silva, Jonathan R., Chen, Jianhan, Zou, Xiaoqin, Cui, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646747/
https://www.ncbi.nlm.nih.gov/pubmed/36351900
http://dx.doi.org/10.1038/s41467-022-34359-6

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