Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution

Germ-line hypomorphism of the pleiotropic transcription factor Myc in mice, either through Myc gene haploinsufficiency or deletion of Myc enhancers, delays onset of various cancers while mice remain viable and exhibit only relatively mild pathologies. Using a genetically engineered mouse model in wh...

Descripción completa

Detalles Bibliográficos
Autores principales: Sodir, Nicole M., Pellegrinet, Luca, Kortlever, Roderik M., Campos, Tania, Kwon, Yong-Won, Kim, Shinseog, Garcia, Daniel, Perfetto, Alessandra, Anastasiou, Panayiotis, Swigart, Lamorna Brown, Arends, Mark J., Littlewood, Trevor D., Evan, Gerard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646778/
https://www.ncbi.nlm.nih.gov/pubmed/36351945
http://dx.doi.org/10.1038/s41467-022-34079-x

Ejemplares similares

Ejemplares similares