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Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation

Although the presence of face patches in primate inferotemporal (IT) cortex is well established, the functional and causal relationships among these patches remain elusive. In two monkeys, muscimol was infused sequentially into each patch or pair of patches to assess their respective influence on th...

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Autores principales: Liu, Ning, Behrmann, Marlene, Turchi, Janita N., Avidan, Galia, Hadj-Bouziane, Fadila, Ungerleider, Leslie G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646786/
https://www.ncbi.nlm.nih.gov/pubmed/36351907
http://dx.doi.org/10.1038/s41467-022-34451-x
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author Liu, Ning
Behrmann, Marlene
Turchi, Janita N.
Avidan, Galia
Hadj-Bouziane, Fadila
Ungerleider, Leslie G.
author_facet Liu, Ning
Behrmann, Marlene
Turchi, Janita N.
Avidan, Galia
Hadj-Bouziane, Fadila
Ungerleider, Leslie G.
author_sort Liu, Ning
collection PubMed
description Although the presence of face patches in primate inferotemporal (IT) cortex is well established, the functional and causal relationships among these patches remain elusive. In two monkeys, muscimol was infused sequentially into each patch or pair of patches to assess their respective influence on the remaining IT face network and the amygdala, as determined using fMRI. The results revealed that anterior face patches required input from middle face patches for their responses to both faces and objects, while the face selectivity in middle face patches arose, in part, from top-down input from anterior face patches. Moreover, we uncovered a parallel fundal-lateral functional organization in the IT face network, supporting dual routes (dorsal-ventral) in face processing within IT cortex as well as between IT cortex and the amygdala. Our findings of the causal relationship among the face patches demonstrate that the IT face circuit is organized into multiple functional compartments.
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spelling pubmed-96467862022-11-15 Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation Liu, Ning Behrmann, Marlene Turchi, Janita N. Avidan, Galia Hadj-Bouziane, Fadila Ungerleider, Leslie G. Nat Commun Article Although the presence of face patches in primate inferotemporal (IT) cortex is well established, the functional and causal relationships among these patches remain elusive. In two monkeys, muscimol was infused sequentially into each patch or pair of patches to assess their respective influence on the remaining IT face network and the amygdala, as determined using fMRI. The results revealed that anterior face patches required input from middle face patches for their responses to both faces and objects, while the face selectivity in middle face patches arose, in part, from top-down input from anterior face patches. Moreover, we uncovered a parallel fundal-lateral functional organization in the IT face network, supporting dual routes (dorsal-ventral) in face processing within IT cortex as well as between IT cortex and the amygdala. Our findings of the causal relationship among the face patches demonstrate that the IT face circuit is organized into multiple functional compartments. Nature Publishing Group UK 2022-11-09 /pmc/articles/PMC9646786/ /pubmed/36351907 http://dx.doi.org/10.1038/s41467-022-34451-x Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Liu, Ning
Behrmann, Marlene
Turchi, Janita N.
Avidan, Galia
Hadj-Bouziane, Fadila
Ungerleider, Leslie G.
Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation
title Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation
title_full Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation
title_fullStr Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation
title_full_unstemmed Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation
title_short Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation
title_sort bidirectional and parallel relationships in macaque face circuit revealed by fmri and causal pharmacological inactivation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646786/
https://www.ncbi.nlm.nih.gov/pubmed/36351907
http://dx.doi.org/10.1038/s41467-022-34451-x
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