Cargando…
Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation
Although the presence of face patches in primate inferotemporal (IT) cortex is well established, the functional and causal relationships among these patches remain elusive. In two monkeys, muscimol was infused sequentially into each patch or pair of patches to assess their respective influence on th...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646786/ https://www.ncbi.nlm.nih.gov/pubmed/36351907 http://dx.doi.org/10.1038/s41467-022-34451-x |
_version_ | 1784827244838912000 |
---|---|
author | Liu, Ning Behrmann, Marlene Turchi, Janita N. Avidan, Galia Hadj-Bouziane, Fadila Ungerleider, Leslie G. |
author_facet | Liu, Ning Behrmann, Marlene Turchi, Janita N. Avidan, Galia Hadj-Bouziane, Fadila Ungerleider, Leslie G. |
author_sort | Liu, Ning |
collection | PubMed |
description | Although the presence of face patches in primate inferotemporal (IT) cortex is well established, the functional and causal relationships among these patches remain elusive. In two monkeys, muscimol was infused sequentially into each patch or pair of patches to assess their respective influence on the remaining IT face network and the amygdala, as determined using fMRI. The results revealed that anterior face patches required input from middle face patches for their responses to both faces and objects, while the face selectivity in middle face patches arose, in part, from top-down input from anterior face patches. Moreover, we uncovered a parallel fundal-lateral functional organization in the IT face network, supporting dual routes (dorsal-ventral) in face processing within IT cortex as well as between IT cortex and the amygdala. Our findings of the causal relationship among the face patches demonstrate that the IT face circuit is organized into multiple functional compartments. |
format | Online Article Text |
id | pubmed-9646786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96467862022-11-15 Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation Liu, Ning Behrmann, Marlene Turchi, Janita N. Avidan, Galia Hadj-Bouziane, Fadila Ungerleider, Leslie G. Nat Commun Article Although the presence of face patches in primate inferotemporal (IT) cortex is well established, the functional and causal relationships among these patches remain elusive. In two monkeys, muscimol was infused sequentially into each patch or pair of patches to assess their respective influence on the remaining IT face network and the amygdala, as determined using fMRI. The results revealed that anterior face patches required input from middle face patches for their responses to both faces and objects, while the face selectivity in middle face patches arose, in part, from top-down input from anterior face patches. Moreover, we uncovered a parallel fundal-lateral functional organization in the IT face network, supporting dual routes (dorsal-ventral) in face processing within IT cortex as well as between IT cortex and the amygdala. Our findings of the causal relationship among the face patches demonstrate that the IT face circuit is organized into multiple functional compartments. Nature Publishing Group UK 2022-11-09 /pmc/articles/PMC9646786/ /pubmed/36351907 http://dx.doi.org/10.1038/s41467-022-34451-x Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Liu, Ning Behrmann, Marlene Turchi, Janita N. Avidan, Galia Hadj-Bouziane, Fadila Ungerleider, Leslie G. Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation |
title | Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation |
title_full | Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation |
title_fullStr | Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation |
title_full_unstemmed | Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation |
title_short | Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation |
title_sort | bidirectional and parallel relationships in macaque face circuit revealed by fmri and causal pharmacological inactivation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646786/ https://www.ncbi.nlm.nih.gov/pubmed/36351907 http://dx.doi.org/10.1038/s41467-022-34451-x |
work_keys_str_mv | AT liuning bidirectionalandparallelrelationshipsinmacaquefacecircuitrevealedbyfmriandcausalpharmacologicalinactivation AT behrmannmarlene bidirectionalandparallelrelationshipsinmacaquefacecircuitrevealedbyfmriandcausalpharmacologicalinactivation AT turchijanitan bidirectionalandparallelrelationshipsinmacaquefacecircuitrevealedbyfmriandcausalpharmacologicalinactivation AT avidangalia bidirectionalandparallelrelationshipsinmacaquefacecircuitrevealedbyfmriandcausalpharmacologicalinactivation AT hadjbouzianefadila bidirectionalandparallelrelationshipsinmacaquefacecircuitrevealedbyfmriandcausalpharmacologicalinactivation AT ungerleiderleslieg bidirectionalandparallelrelationshipsinmacaquefacecircuitrevealedbyfmriandcausalpharmacologicalinactivation |