Anti-neoplastic sulfonamides alter the metabolic homeostasis and disrupt the suppressor activity of regulatory T cells

Regulatory T cells (Tregs) are essential to maintain self-tolerance and immune homeostasis but, as components of the tumor microenvironment (TME), are also a major barrier to effective cancer immunosurveillance and immunotherapy. FH535 and its derivative Y3 are two N-aryl-benzene-sulfonamides (NABs)...

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Detalles Bibliográficos
Autores principales: Gedaly, Roberto, Cornea, Virgilius, Turcios, Lilia, Edmisson, Jacob S., Harris, Dwight D., Watt, David S., Chapelin, Fanny, Khurana, Aman, Mei, Xiaonan, Liu, Chunming, Taylor, Isaac, Gonzalez-Valdivieso, Juan, Mitchel, Hunter, Ruffing, Alexis, Chishti, Asir, Orozco, Gabriel, Zwischenberger, Joseph, Evers, B. Mark, Marti, Francesc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646802/
https://www.ncbi.nlm.nih.gov/pubmed/36352020
http://dx.doi.org/10.1038/s41598-022-23601-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646802/
https://www.ncbi.nlm.nih.gov/pubmed/36352020
http://dx.doi.org/10.1038/s41598-022-23601-2

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