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Driven translocation of a semiflexible polymer through a conical channel in the presence of attractive surface interactions

We study the translocation of a semiflexible polymer through a conical channel with attractive surface interactions and a driving force which varies spatially inside the channel. Using the results of the translocation dynamics of a flexible polymer through an extended channel as control, we first sh...

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Autores principales: Sharma, Andri, Kapri, Rajeev, Chaudhuri, Abhishek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646819/
https://www.ncbi.nlm.nih.gov/pubmed/36351960
http://dx.doi.org/10.1038/s41598-022-21845-6
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author Sharma, Andri
Kapri, Rajeev
Chaudhuri, Abhishek
author_facet Sharma, Andri
Kapri, Rajeev
Chaudhuri, Abhishek
author_sort Sharma, Andri
collection PubMed
description We study the translocation of a semiflexible polymer through a conical channel with attractive surface interactions and a driving force which varies spatially inside the channel. Using the results of the translocation dynamics of a flexible polymer through an extended channel as control, we first show that the asymmetric shape of the channel gives rise to non-monotonic features in the total translocation time as a function of the apex angle of the channel. The waiting time distributions of individual monomer beads inside the channel show unique features strongly dependent on the driving force and the surface interactions. Polymer stiffness results in longer translocation times for all angles of the channel. Further, non-monotonic features in the translocation time as a function of the channel angle changes substantially as the polymer becomes stiffer, which is reflected in the changing features of the waiting time distributions. We construct a free energy description of the system incorporating entropic and energetic contributions in the low force regime to explain the simulation results.
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spelling pubmed-96468192022-11-15 Driven translocation of a semiflexible polymer through a conical channel in the presence of attractive surface interactions Sharma, Andri Kapri, Rajeev Chaudhuri, Abhishek Sci Rep Article We study the translocation of a semiflexible polymer through a conical channel with attractive surface interactions and a driving force which varies spatially inside the channel. Using the results of the translocation dynamics of a flexible polymer through an extended channel as control, we first show that the asymmetric shape of the channel gives rise to non-monotonic features in the total translocation time as a function of the apex angle of the channel. The waiting time distributions of individual monomer beads inside the channel show unique features strongly dependent on the driving force and the surface interactions. Polymer stiffness results in longer translocation times for all angles of the channel. Further, non-monotonic features in the translocation time as a function of the channel angle changes substantially as the polymer becomes stiffer, which is reflected in the changing features of the waiting time distributions. We construct a free energy description of the system incorporating entropic and energetic contributions in the low force regime to explain the simulation results. Nature Publishing Group UK 2022-11-09 /pmc/articles/PMC9646819/ /pubmed/36351960 http://dx.doi.org/10.1038/s41598-022-21845-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sharma, Andri
Kapri, Rajeev
Chaudhuri, Abhishek
Driven translocation of a semiflexible polymer through a conical channel in the presence of attractive surface interactions
title Driven translocation of a semiflexible polymer through a conical channel in the presence of attractive surface interactions
title_full Driven translocation of a semiflexible polymer through a conical channel in the presence of attractive surface interactions
title_fullStr Driven translocation of a semiflexible polymer through a conical channel in the presence of attractive surface interactions
title_full_unstemmed Driven translocation of a semiflexible polymer through a conical channel in the presence of attractive surface interactions
title_short Driven translocation of a semiflexible polymer through a conical channel in the presence of attractive surface interactions
title_sort driven translocation of a semiflexible polymer through a conical channel in the presence of attractive surface interactions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646819/
https://www.ncbi.nlm.nih.gov/pubmed/36351960
http://dx.doi.org/10.1038/s41598-022-21845-6
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